{"id":"W1998299865","doi":"10.1002/hep.23250","title":"Increased Tumor Necrosis Factor α–Converting Enzyme Activity Induces Insulin Resistance and Hepatosteatosis in Mice","year":2009,"lang":"en","type":"article","venue":"Hepatology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Fondazione Roma","keywords":"Internal medicine; Endocrinology; Insulin resistance; Steatosis; Fatty liver; Adipose tissue; Insulin; Biology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003595244,0.001247958,0.000533117,0.0009508273,0.0003003691,0.0006527441,0.0003713566,0.0006125678,0.003204201],"category_scores_gemma":[0.0001379638,0.0005247501,0.0008335964,0.0005651316,0.0007225268,0.0004069719,0.0004160528,0.001643253,0.00117716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005628156,"about_ca_system_score_gemma":0.0002345499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002764435,"about_ca_topic_score_gemma":0.0004512276,"domain_scores_codex":[0.9995864,0.00005663082,0.00006060346,0.0001224678,0.00008083987,0.00009308171],"domain_scores_gemma":[0.9994857,0.00003368546,0.0002612854,0.00005415556,0.00002435341,0.0001407784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001000449,0.0001683227,0.0006766001,0.00006930981,0.00002078256,0.0001826452,0.00002503006,0.00004762767,0.9963212,0.00008918674,0.00006970535,0.001329183],"study_design_scores_gemma":[0.0003818316,0.002920006,0.01791976,0.00004157381,0.0001486666,0.001935205,0.0001401136,0.00084654,0.9699972,0.0001749495,0.005470306,0.00002379259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908354,0.001863905,0.003643441,0.0002462305,0.00009504011,0.00008018123,0.001150562,0.0004583466,0.001626782],"genre_scores_gemma":[0.9844564,0.001962557,0.003683524,0.0002428382,0.00005463326,0.000228185,0.001706969,0.0001669737,0.007497899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003204201,"threshold_uncertainty_score":0.01071912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128216164384535,"score_gpt":0.244014942562399,"score_spread":0.2311933261239455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}