{"id":"W1998439395","doi":"10.1002/jps.20680","title":"Thiol exchange: An in vitro assay that predicts the efficacy of novel homocysteine lowering therapies","year":2006,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; Health Research Board; Lawson Health Research Institute","keywords":"Thiol; Homocysteine; In vitro; Chemistry; Pharmacology; Biochemistry; Combinatorial chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003364654,0.0001013223,0.0002706488,0.0002236702,0.00009524043,0.00004675922,0.000376093,0.00005070936,0.0001101081],"category_scores_gemma":[0.0001855254,0.00005021356,0.0001015898,0.0005748028,0.0005676426,0.0002877284,0.0000601526,0.0004184417,0.000001609443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004790396,"about_ca_system_score_gemma":0.0001610636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006954846,"about_ca_topic_score_gemma":0.00001488268,"domain_scores_codex":[0.9979897,0.00011269,0.0003845161,0.0001344701,0.001049719,0.0003288878],"domain_scores_gemma":[0.9990528,0.0004191081,0.0001505298,0.0001092277,0.0001248882,0.0001434599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000708414,0.001123775,0.0159318,0.00006522574,0.00004093478,0.00008613559,0.0004956702,0.0001364938,0.9578457,0.0000708097,0.0001417591,0.0233533],"study_design_scores_gemma":[0.008583144,0.002141608,0.1944414,0.0004049592,0.0001277337,0.0006196291,0.001179888,0.01819653,0.766933,0.0001359046,0.007037164,0.0001990822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918442,0.002864129,0.000191656,0.003492888,0.000159717,0.0001806656,0.000003353189,0.000006280979,0.001257093],"genre_scores_gemma":[0.9986848,0.0002691107,0.0004445138,0.0001702374,0.0003468205,0.00000155792,5.795961e-7,0.000006010742,0.00007639609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1909127,"threshold_uncertainty_score":0.2091503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109787049719252,"score_gpt":0.4147316184453783,"score_spread":0.3049445687261263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}