{"id":"W1998454551","doi":"10.1371/journal.ppat.1001080","title":"Formation of Mobile Chromatin-Associated Nuclear Foci Containing HIV-1 Vpr and VPRBP Is Critical for the Induction of G2 Cell Cycle Arrest","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Chromatin; Cell biology; Cell cycle checkpoint; Biology; Ubiquitin ligase; DNA damage; G2-M DNA damage checkpoint; Ubiquitin; Molecular biology; Cell cycle; Cajal body; Nuclear protein; DNA; Cell; Genetics; Transcription factor; Gene; RNA splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000191029,0.00008455257,0.0001293049,0.00001992752,0.00008051575,0.000009705127,0.00008667635,0.0001482539,0.00001607418],"category_scores_gemma":[0.0002502569,0.00007208932,0.00006677317,0.00003786217,0.00007811287,0.000008168407,0.00005275279,0.00007577115,0.000001821181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006046083,"about_ca_system_score_gemma":0.00001940213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003919171,"about_ca_topic_score_gemma":0.000008071445,"domain_scores_codex":[0.9993833,0.00002971811,0.00020853,0.0001456094,0.00009687871,0.0001359579],"domain_scores_gemma":[0.999431,0.00005824376,0.0001330718,0.0001996951,0.0001422858,0.00003567886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002944226,0.00009484978,0.0001148158,0.00006849632,0.00002161111,1.971454e-7,0.0004573045,0.000004507313,0.998477,0.0001510735,0.00009674468,0.0004839578],"study_design_scores_gemma":[0.0004151841,0.0004635714,0.0004666254,0.00001837197,0.00006911242,0.000003207243,0.000875994,0.004629799,0.9924843,0.0001592827,0.0003292984,0.00008528724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984648,0.00007081507,0.0006117005,0.00006763417,0.00009516794,0.000316913,0.0001856652,0.00001150662,0.0001758075],"genre_scores_gemma":[0.9978998,0.00002388226,0.001824022,0.00005113225,0.00006658631,0.00004269756,0.00005306865,0.00001961132,0.00001918905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005992733,"threshold_uncertainty_score":0.2939717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009785324275753828,"score_gpt":0.2352799550664253,"score_spread":0.2254946307906715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}