{"id":"W1998456096","doi":"10.1002/jbm.b.31289","title":"Release and activity of anti‐TNFα therapeutics from injectable chitosan preparations for local drug delivery","year":2008,"lang":"en","type":"article","venue":"Journal of Biomedical Materials Research Part B Applied Biomaterials","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Curcumin; Tumor necrosis factor alpha; Pharmacology; Bioavailability; Chitosan; Chemistry; Cytokine; Drug delivery; In vitro; Drug; Bovine serum albumin; In vivo; Antibody; Medicine; Immunology; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003743279,0.0002931777,0.001080791,0.0003927105,0.0004545482,0.00005506877,0.0004558965,0.0004825055,0.0004187778],"category_scores_gemma":[0.000207092,0.0002337337,0.0001124665,0.0003227586,0.00182496,0.0002403354,0.0002253398,0.0002700037,0.00002090414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008107106,"about_ca_system_score_gemma":0.0004664213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001079048,"about_ca_topic_score_gemma":0.000004502833,"domain_scores_codex":[0.9951885,0.001421513,0.001483891,0.0003840034,0.0007912043,0.0007308692],"domain_scores_gemma":[0.9962928,0.001616297,0.0008869225,0.0002878352,0.0004067663,0.0005093938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004842994,0.0006610343,0.00008938701,0.0001791792,0.0004071534,0.00004736899,0.0005794017,0.00002523659,0.9855887,0.00005780851,0.004914233,0.002607511],"study_design_scores_gemma":[0.002665292,0.0004498916,0.0003824619,0.00006779846,0.0001060324,0.00009589892,0.0002151429,0.0001251647,0.9643282,0.0005104633,0.03084512,0.0002085886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935115,0.0004933337,0.00107396,0.0004050481,0.001869972,0.001074025,0.001491047,0.00003090387,0.00005021031],"genre_scores_gemma":[0.9955899,0.001807382,0.0008781037,0.0001063082,0.001373043,0.0000994534,0.00007583128,0.00004052173,0.0000294881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02593089,"threshold_uncertainty_score":0.9531385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1709401637859457,"score_gpt":0.4553772246044648,"score_spread":0.2844370608185191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}