{"id":"W1998456096","doi":"10.1002/jbm.b.31289","title":"Release and activity of anti‐TNFα therapeutics from injectable chitosan preparations for local drug delivery","year":2008,"lang":"en","type":"article","venue":"Journal of Biomedical Materials Research Part B Applied Biomaterials","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Curcumin; Tumor necrosis factor alpha; Pharmacology; Bioavailability; Chitosan; Chemistry; Cytokine; Drug delivery; In vitro; Drug; Bovine serum albumin; In vivo; Antibody; Medicine; Immunology; Biochemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167647,0.0006057053,0.0001801934,0.0002885481,0.000142501,0.0002256417,0.0002059915,0.0002449322,0.001253927],"category_scores_gemma":[0.0002667629,0.0001357067,0.0003232679,0.0002226489,0.0002201997,0.0002089803,0.0001067258,0.0004075523,0.0002738055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004981571,"about_ca_system_score_gemma":0.0002640749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009753624,"about_ca_topic_score_gemma":0.001267514,"domain_scores_codex":[0.9998747,0.00001308277,0.00001165181,0.00002602599,0.00004873343,0.00002574167],"domain_scores_gemma":[0.9997773,0.00003485685,0.00009540321,0.00001717699,0.00004339656,0.00003193079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001068342,0.0000239268,0.00007266901,0.00006908185,0.0000060215,0.00003372575,0.000009767122,0.0001444295,0.9967123,0.00002388986,0.00002348286,0.002773823],"study_design_scores_gemma":[0.00001791979,0.0004828564,0.0007823859,0.000009279134,0.0000222809,0.00007317045,0.000004799164,0.000426543,0.9976374,0.00000615957,0.0005327901,0.000004432072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810109,0.004780506,0.01109095,0.0000863352,0.00004840352,0.0001921733,0.0002974918,0.0001235042,0.002369831],"genre_scores_gemma":[0.9875057,0.002603464,0.006933616,0.00003772469,0.00002204221,0.0001103327,0.0002574668,0.0000433075,0.002486435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253927,"threshold_uncertainty_score":0.004194796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1709401637859457,"score_gpt":0.4553772246044648,"score_spread":0.2844370608185191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}