{"id":"W1998473130","doi":"10.1021/jm050644n","title":"Design and Synthesis of Photoaffinity-Labeling Ligands of the<scp>l</scp>-Prolyl-<scp>l</scp>-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Chemistry; Allosteric regulation; Photoaffinity labeling; Stereochemistry; Binding site; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350132,0.0004799066,0.0003645951,0.0001548035,0.0001664528,0.0002374883,0.000398858,0.0004410309,0.0009526846],"category_scores_gemma":[0.0001807701,0.0002269624,0.000231178,0.0002039737,0.0002013608,0.0002715108,0.0001696767,0.0006037813,0.0005852573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005520957,"about_ca_system_score_gemma":0.0003831447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000489008,"about_ca_topic_score_gemma":0.001082416,"domain_scores_codex":[0.9998949,0.00001993312,0.00000869882,0.00002409176,0.00002599193,0.00002644454],"domain_scores_gemma":[0.9998673,0.00001890647,0.00005872671,0.000008440528,0.00001513092,0.00003136724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005444886,0.00002670131,0.00004580542,0.00005007651,0.000004335934,0.00004252193,0.00001005444,0.0003186937,0.9968997,0.0001877537,0.00003934079,0.002320691],"study_design_scores_gemma":[0.00004349066,0.0004138711,0.0004464836,0.0000060246,0.00001427827,0.0001990727,0.00001191541,0.0008482622,0.9939328,0.00003732565,0.004035034,0.00001131824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583664,0.00323267,0.03340125,0.0002285862,0.0000644693,0.0005217185,0.000401425,0.0002191522,0.003564315],"genre_scores_gemma":[0.8999263,0.003790609,0.08772063,0.0003470237,0.00003781832,0.0005150421,0.001245688,0.00006016186,0.006356753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009526846,"threshold_uncertainty_score":0.00400579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158556297086222,"score_gpt":0.2241017765659972,"score_spread":0.212516213595135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}