{"id":"W1998473130","doi":"10.1021/jm050644n","title":"Design and Synthesis of Photoaffinity-Labeling Ligands of the<scp>l</scp>-Prolyl-<scp>l</scp>-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Chemistry; Allosteric regulation; Photoaffinity labeling; Stereochemistry; Binding site; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474179,0.0002006632,0.0004769704,0.0000532273,0.00006429102,0.00001241483,0.0005316795,0.0001992484,0.000006646076],"category_scores_gemma":[0.003223854,0.0001120371,0.0002673031,0.000342029,0.0002271013,0.00001369147,0.0001214585,0.0003181772,2.212528e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003586657,"about_ca_system_score_gemma":0.00009893219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189839,"about_ca_topic_score_gemma":0.000004693924,"domain_scores_codex":[0.998042,0.0001347641,0.0008743146,0.0001957156,0.0005446081,0.0002086149],"domain_scores_gemma":[0.9973461,0.0008239531,0.001206693,0.0003450576,0.0002049593,0.00007325235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003581319,0.0001453833,0.007617433,0.0001641915,0.0001162168,0.000001257111,0.0003046376,0.0004339682,0.9899108,3.500666e-7,0.0002546554,0.00101534],"study_design_scores_gemma":[0.0006065456,0.00008195823,0.002134147,0.0005357281,0.0002256694,0.00004010824,0.001150026,0.0007753973,0.9939464,0.00001366827,0.0004531229,0.00003724244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975743,0.001725193,0.0001223516,0.0002810643,0.00003733662,0.0001069826,0.00001150768,0.000001463717,0.0001398202],"genre_scores_gemma":[0.9983236,0.000728261,0.0005086329,0.00006972763,0.000256554,0.000004608788,0.000005034106,0.0000157941,0.00008777584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005483286,"threshold_uncertainty_score":0.4568741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158556297086222,"score_gpt":0.2241017765659972,"score_spread":0.212516213595135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}