{"id":"W1998475020","doi":"10.1016/j.neuron.2013.11.015","title":"Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation","year":2014,"lang":"en","type":"article","venue":"Neuron","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":200,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Nautical Research Society","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; George Washington University","keywords":"Remyelination; Lesion; Notch signaling pathway; Neuroscience; Biology; Endogeny; Myelin; Cell biology; Progenitor cell; Oligodendrocyte; Stem cell; Signal transduction; Medicine; Pathology; Central nervous system; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216436,0.0002312211,0.0002032806,0.0001289611,0.0002984544,0.0001295377,0.0002307247,0.00007734629,0.00006915686],"category_scores_gemma":[0.00134848,0.0002358487,0.00008349003,0.000289879,0.00006005594,0.0004020322,0.00009433764,0.0002394533,0.0003575425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003296816,"about_ca_system_score_gemma":0.00002661815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001284705,"about_ca_topic_score_gemma":0.000004547825,"domain_scores_codex":[0.9977309,0.0003798427,0.0003172028,0.0007112299,0.000497855,0.0003630228],"domain_scores_gemma":[0.9987907,0.0005171805,0.0001956971,0.0003597217,0.00005308401,0.00008361359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000599535,0.00007135371,0.000007540065,0.00001156371,6.964619e-7,0.000004692811,0.00005948917,0.0001366343,0.9906654,0.005359083,0.00007045278,0.003553176],"study_design_scores_gemma":[0.0005623902,0.0003366833,0.0003902278,0.00001563703,0.00000808957,0.00002437721,0.000004242742,0.002376644,0.9840512,0.000367866,0.01167736,0.0001852489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759737,0.00000177411,0.01917145,0.0005821689,0.000669327,0.0002846857,0.000008209233,0.0002902373,0.003018389],"genre_scores_gemma":[0.9950235,0.00004017381,0.0003177922,0.003916594,0.0002639041,0.0000218591,0.000003030125,0.000063269,0.0003498387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01904978,"threshold_uncertainty_score":0.9617629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03616079522394901,"score_gpt":0.2555731867360992,"score_spread":0.2194123915121502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}