{"id":"W1998478034","doi":"10.1158/1078-0432.ccr-07-4475","title":"Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Hôtel-Dieu de Québec; Vancouver General Hospital","funders":"","keywords":"In vivo; Medicine; Bladder cancer; Bioluminescence imaging; Urinary bladder; In vitro; Cytotoxicity; Cancer; Urology; Chemotherapy; Cancer research; Pathology; Luciferase; Cell culture; Chemistry; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00150146,0.0002026346,0.0007923047,0.0001194187,0.0001113989,0.000007392582,0.0004411542,0.0001743561,0.001592666],"category_scores_gemma":[0.000807725,0.0001033286,0.0002059499,0.0009387098,0.002240671,0.00004323664,0.0002022065,0.001191957,0.000007227297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000104156,"about_ca_system_score_gemma":0.0009669983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003296234,"about_ca_topic_score_gemma":0.0006540177,"domain_scores_codex":[0.996819,0.0003721849,0.0007510711,0.0006433572,0.0009206363,0.0004937691],"domain_scores_gemma":[0.9974411,0.0004882973,0.0002099715,0.0009141024,0.0007555261,0.0001910577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02390382,0.005156535,0.2099507,0.001958327,0.001951727,0.0001831844,0.0009785456,0.00002688178,0.4591098,0.0003268809,0.04654723,0.2499063],"study_design_scores_gemma":[0.002890622,0.001186446,0.3701986,0.0006463429,0.0001445429,0.00007792404,0.00004598897,0.00003001639,0.6141304,0.00008336649,0.01034982,0.0002159997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699619,0.0009393401,0.000001581049,0.02770323,0.0001710356,0.0009681202,0.00004992847,0.00001436933,0.0001905398],"genre_scores_gemma":[0.9918848,0.003861295,0.0002968333,0.0004994876,0.0009333664,0.0000188709,0.000005499076,0.00003908449,0.002460769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2496904,"threshold_uncertainty_score":0.99932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1212391944337563,"score_gpt":0.4175410524560927,"score_spread":0.2963018580223364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}