{"id":"W1998478034","doi":"10.1158/1078-0432.ccr-07-4475","title":"Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval; Hôtel-Dieu de Québec; Vancouver General Hospital","funders":"","keywords":"In vivo; Medicine; Bladder cancer; Bioluminescence imaging; Urinary bladder; In vitro; Cytotoxicity; Cancer; Urology; Chemotherapy; Cancer research; Pathology; Luciferase; Cell culture; Chemistry; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215486,0.0001824852,0.0002738564,0.000148291,0.00008265425,0.0001433632,0.0001684255,0.0001579311,0.0006053607],"category_scores_gemma":[0.00008267065,0.00007126016,0.0001388506,0.0001338768,0.0001672309,0.0001041507,0.0001184846,0.0003263577,0.0001212228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011422,"about_ca_system_score_gemma":0.0002034258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004149438,"about_ca_topic_score_gemma":0.0008002964,"domain_scores_codex":[0.9999536,0.00001053939,0.000004078975,0.000008186416,0.0000114445,0.00001209304],"domain_scores_gemma":[0.9999293,0.00001319694,0.00002459373,0.000008942844,0.000005855974,0.00001815166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.001200185,0.0002737748,0.000903966,0.0002445896,0.00002467047,0.0001795932,0.0000349416,0.0006727713,0.9836844,0.00006250674,0.0001103136,0.01260836],"study_design_scores_gemma":[0.0001432298,0.00992033,0.007035295,0.0000155182,0.00006230058,0.0007770403,0.00002862253,0.001579242,0.9782677,0.00001682112,0.002146274,0.000007755057],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956677,0.002585385,0.0008979041,0.00003884633,0.00002027284,0.00003790613,0.00008957201,0.00004231478,0.0006200399],"genre_scores_gemma":[0.9974955,0.00104312,0.0008435464,0.00001577707,0.00000918216,0.00001468583,0.0001189007,0.000004168993,0.0004550162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006053607,"threshold_uncertainty_score":0.002025187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1212391944337563,"score_gpt":0.4175410524560927,"score_spread":0.2963018580223364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}