{"id":"W1998481715","doi":"10.1111/cas.12442","title":"Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis","year":2014,"lang":"en","type":"article","venue":"Cancer Science","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Japan Society for the Promotion of Science; Ministry of Health, Labour and Welfare; Ministry of Education, Culture, Sports, Science and Technology; Takeda Science Foundation","keywords":"Lymphoma; CDKN2A; Mantle cell lymphoma; Follicular lymphoma; Genetic heterogeneity; Somatic evolution in cancer; Biology; Comparative genomic hybridization; Cell of origin; Chronic lymphocytic leukemia; Aggressive lymphoma; Cancer research; Leukemia; Pathology; Immunology; Cancer; Medicine; Gene; Phenotype; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963315,0.000115691,0.0001859048,0.000904529,0.0002419226,0.0003150675,0.0001333893,0.0002116814,0.00129369],"category_scores_gemma":[0.001277844,0.0001078007,0.0001253655,0.0004628581,0.0002374536,0.0002216741,0.0003021458,0.0002278675,0.0001491618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500057,"about_ca_system_score_gemma":0.0001015038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004364676,"about_ca_topic_score_gemma":0.0007864843,"domain_scores_codex":[0.9998127,0.00004449267,0.00001882053,0.00003656818,0.00004316402,0.00004431009],"domain_scores_gemma":[0.9989113,0.0002793157,0.000460911,0.00007223915,0.00009897962,0.0001772941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001342519,0.000009285698,0.9924839,0.000004828552,0.00002827168,0.0002389862,0.00003332234,0.00008442353,0.004031401,0.00002282686,0.00005322007,0.002875161],"study_design_scores_gemma":[0.000003252985,0.00005154993,0.9974221,0.00000250268,0.00002024813,0.001427551,0.00006528514,0.0002411629,0.0005335931,0.00008157219,0.0001480315,0.000003174232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994429,0.0001838716,0.0001034125,0.00001546562,0.000001315855,0.000001673411,0.00003509806,0.000003228884,0.0002130614],"genre_scores_gemma":[0.9997938,0.00004725132,0.00003870413,0.000004772415,0.000004653862,0.000001393347,0.00005951468,8.228329e-7,0.00004907675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129369,"threshold_uncertainty_score":0.004327834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504303065105711,"score_gpt":0.2735225468366568,"score_spread":0.2584795161855997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}