{"id":"W1998502163","doi":"10.1007/s00232-010-9255-4","title":"The Role of Extramembranous Cytoplasmic Termini in Assembly and Stability of the Tetrameric K+-Channel KcsA","year":2010,"lang":"en","type":"article","venue":"The Journal of Membrane Biology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Universiteit Utrecht","keywords":"KcsA potassium channel; Tetramer; Chemistry; Biophysics; Lipid bilayer; Phosphatidylglycerol; Bilayer; Cytoplasm; Integral membrane protein; Membrane protein; Ion channel; Membrane; Phosphatidylcholine; Crystallography; Biochemistry; Biology; Phospholipid; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001073001,0.00009021874,0.0001772019,0.00003653904,0.00007178744,0.000004452127,0.0002866502,0.0001420882,0.000008483812],"category_scores_gemma":[0.0002841002,0.00004215217,0.00008610418,0.00009224923,0.0004394518,0.000004472911,0.00006677028,0.0002410304,2.524354e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004982136,"about_ca_system_score_gemma":0.00008107844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002583438,"about_ca_topic_score_gemma":0.0001029268,"domain_scores_codex":[0.999027,0.0002651438,0.0004021829,0.00008648389,0.00008840298,0.0001308075],"domain_scores_gemma":[0.9989961,0.0001682399,0.0004204999,0.0002587042,0.0001273385,0.00002908586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003439866,0.0000424725,0.003795765,0.000008672364,0.00002334321,1.322598e-7,0.0001612868,0.00005124211,0.9917083,0.00008496006,0.00001207829,0.003767695],"study_design_scores_gemma":[0.000602441,0.0003972556,0.01788544,0.00001040858,0.0000231553,0.0001556734,0.0006678618,0.0003767303,0.9760639,0.0006521921,0.00310291,0.00006204574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979934,0.000633854,0.00006510223,0.0004098582,0.0005776169,0.0001121417,0.00000580541,0.000001070929,0.0002012051],"genre_scores_gemma":[0.9992741,0.0004808316,0.00002136857,0.00004651115,0.0001438685,0.000001399346,0.00000152492,0.00000630893,0.00002404268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01564447,"threshold_uncertainty_score":0.1718916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006748630605623457,"score_gpt":0.2285343493405351,"score_spread":0.2217857187349116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}