{"id":"W1998509546","doi":"10.1016/j.tetlet.2011.03.042","title":"RNA synthesis via dimer and trimer phosphoramidite block coupling","year":2011,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Phosphoramidite; Trimer; Chemistry; Dimer; Solid-phase synthesis; Combinatorial chemistry; RNA; Sequence (biology); Oligonucleotide; Stereochemistry; Organic chemistry; Biochemistry; DNA; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000422212,0.0005346335,0.0005328013,0.0003917993,0.0003748299,0.0003431987,0.0006537445,0.0005525372,0.003677571],"category_scores_gemma":[0.0002343339,0.000349393,0.0004078075,0.0002972228,0.0002321959,0.0003793052,0.0003859166,0.0008517571,0.001913784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005102326,"about_ca_system_score_gemma":0.0004337753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005095644,"about_ca_topic_score_gemma":0.0008355054,"domain_scores_codex":[0.9996862,0.00006241496,0.00002317008,0.00008547319,0.00006298174,0.00007980848],"domain_scores_gemma":[0.9998708,0.00002232741,0.00002997092,0.00003408916,0.00001881749,0.00002400225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209823,0.00004485486,0.0000433259,0.00008399273,0.000008952229,0.00007378282,0.00004243862,0.0002417389,0.9926313,0.001521667,0.0002754462,0.004911512],"study_design_scores_gemma":[0.00002136298,0.0002052377,0.0001012651,0.000002509809,0.000008386593,0.00006911903,0.000005313753,0.0008184962,0.9955031,0.0001387087,0.003117332,0.000009130663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7825742,0.004094512,0.166973,0.0008255832,0.0004937467,0.0005093654,0.0008002202,0.002617762,0.04111169],"genre_scores_gemma":[0.93577,0.00121533,0.04031661,0.0001817689,0.00005135357,0.0002677217,0.0004839005,0.0002249136,0.02148849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003677571,"threshold_uncertainty_score":0.0123027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620875356758967,"score_gpt":0.2121822154579106,"score_spread":0.1959734618903209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}