{"id":"W1998509546","doi":"10.1016/j.tetlet.2011.03.042","title":"RNA synthesis via dimer and trimer phosphoramidite block coupling","year":2011,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Phosphoramidite; Trimer; Chemistry; Dimer; Solid-phase synthesis; Combinatorial chemistry; RNA; Sequence (biology); Oligonucleotide; Stereochemistry; Organic chemistry; Biochemistry; DNA; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078507,0.0001764633,0.0001434454,0.00004596069,0.00006437505,0.00001887094,0.0001590491,0.0001090969,0.00009708839],"category_scores_gemma":[0.00002379653,0.000166479,0.00007650308,0.00005114916,0.0001093521,0.000006481667,0.00006433531,0.00009183955,0.00005200016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009134249,"about_ca_system_score_gemma":0.00001280598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000103787,"about_ca_topic_score_gemma":0.000006863305,"domain_scores_codex":[0.999112,0.00001739385,0.0001682965,0.0003508058,0.00009089069,0.0002606036],"domain_scores_gemma":[0.9995402,0.00001464164,0.00005552978,0.000279383,0.00002668355,0.00008356779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007777834,0.00003097115,0.003116698,0.000008851724,0.00008956675,0.000009575038,0.00008421029,0.00001227897,0.9901599,0.000004152713,0.002786074,0.003619979],"study_design_scores_gemma":[0.0002012111,0.0001305074,0.007760502,0.00001763196,0.00005793026,0.000020094,0.00004526054,0.0001277564,0.9886838,0.0000101755,0.002669383,0.0002758008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970702,0.0009302511,0.0007405913,0.0001683708,0.0001845355,0.00009371826,0.000007460867,0.00002081877,0.0007840691],"genre_scores_gemma":[0.9975739,0.0002199106,0.0004698396,0.001361,0.0001340403,0.00001563598,0.000008075567,0.00002613515,0.0001914397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004643803,"threshold_uncertainty_score":0.6788815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620875356758967,"score_gpt":0.2121822154579106,"score_spread":0.1959734618903209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}