{"id":"W1998512738","doi":"10.1081/scc-100000584","title":"RESOLUTION OF CHIRAL ALIPHATIC AND ARYLALKYL AMINES USING IMMOBILIZED<i>CANDIDA ANTARCTICA</i>LIPASE AND ISOLATION OF THEIR R- AND S-ENANTIOMERS","year":2001,"lang":"en","type":"article","venue":"Synthetic Communications","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Novo Nordisk","keywords":"Chemistry; Candida antarctica; Enantiomer; Lipase; Enantiomeric excess; Resolution (logic); Amine gas treating; Yield (engineering); Organic chemistry; Chromatography; Enantioselective synthesis; Enzyme; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001829557,0.00009389179,0.0001572459,0.00007417789,0.0001169786,0.00001273102,0.0001056812,0.00006009813,0.000003373653],"category_scores_gemma":[0.00009172172,0.00008470685,0.00003271421,0.0001358751,0.0004274427,0.00001370452,0.0001726264,0.00003862863,9.283119e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005989308,"about_ca_system_score_gemma":0.00001822346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009549591,"about_ca_topic_score_gemma":0.00006819045,"domain_scores_codex":[0.9993331,0.00009520067,0.0002661324,0.0001629504,0.00005369585,0.00008887957],"domain_scores_gemma":[0.9990823,0.00005771518,0.0001584256,0.0005771804,0.0000875383,0.00003682625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003962636,0.00009149778,0.01001636,0.00004969641,0.00004609021,5.901911e-8,0.0003334837,0.00002824911,0.9856093,0.000466204,0.000006436248,0.003313004],"study_design_scores_gemma":[0.004143231,0.001366172,0.08693306,0.0008502633,0.00100625,0.0003954903,0.007472782,0.1431862,0.7406319,0.002979706,0.009818658,0.00121634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908702,0.006216433,0.002361333,0.0001739077,0.00001386523,0.0001648708,0.00002185569,0.000004123696,0.0001733954],"genre_scores_gemma":[0.990624,0.006994657,0.002210204,0.00001352997,0.000009153379,0.00000859341,0.0001014496,0.000009847775,0.00002858303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2449774,"threshold_uncertainty_score":0.3454245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01929943035778687,"score_gpt":0.2701750272542539,"score_spread":0.250875596896467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}