{"id":"W1998528347","doi":"10.1074/jbc.m210919200","title":"A Fast-acting, Modular-structured Staphylokinase Fusion with Kringle-1 from Human Plasminogen as the Fibrin-targeting Domain Offers Improved Clot Lysis Efficacy","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; University of Notre Dame; Heart and Stroke Foundation of Canada","keywords":"Staphylokinase; Pichia pastoris; Fusion protein; Lysis; Fibrin; Kringle domain; Chemistry; Plasmin; Biochemistry; Biology; Recombinant DNA; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002988101,0.0002280019,0.0002479647,0.00001799547,0.0002041061,0.00005085583,0.0002510555,0.0002408952,0.0002053573],"category_scores_gemma":[0.0003423917,0.0001348614,0.0001753975,0.0001056433,0.0001244611,0.000008505054,0.00006497375,0.0003063972,0.00000126522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003005206,"about_ca_system_score_gemma":0.00005586063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005733939,"about_ca_topic_score_gemma":0.000001170563,"domain_scores_codex":[0.9986923,0.0001213623,0.0004333814,0.0003369635,0.000180707,0.0002352843],"domain_scores_gemma":[0.9988304,0.00002698647,0.0005867208,0.000265038,0.000164434,0.0001264119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003469717,0.00008226026,0.002147308,0.000009839186,0.0001132388,0.000009846462,0.00007017361,0.0000738378,0.996546,0.00000449638,0.0000615686,0.0005344442],"study_design_scores_gemma":[0.0008462211,0.0003234853,0.002214695,0.00002234743,0.00003425259,0.00008807253,0.0004705851,0.000006789652,0.9875661,0.00007589377,0.008152681,0.0001988968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986807,0.0002053179,0.0004419925,0.0001409057,0.00008711224,0.00009969983,0.00001855978,0.0000112604,0.0003144376],"genre_scores_gemma":[0.9977757,0.00007944257,0.001155867,0.0001376943,0.0005529575,0.000003772705,0.0001620947,0.00001840097,0.0001140167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008979936,"threshold_uncertainty_score":0.5499489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023499924096138,"score_gpt":0.2289150428373168,"score_spread":0.2186800435963554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}