{"id":"W1998566517","doi":"10.1002/stem.1368","title":"Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers","year":2013,"lang":"en","type":"article","venue":"Stem Cells","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Korea Research Institute of Bioscience and Biotechnology; Canadian Institutes of Health Research; Korea Research Council of Fundamental Science and Technology","keywords":"Reprogramming; NAD+ kinase; Biology; Induced pluripotent stem cell; Cell biology; Embryonic stem cell; Nicotinamide phosphoribosyltransferase; Stem cell; Intracellular; Somatic cell; Biochemistry; Cell; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301369,0.0003831935,0.0003189383,0.0001853878,0.0001247991,0.000295386,0.000272063,0.0002795738,0.0008670547],"category_scores_gemma":[0.0001415897,0.00007203755,0.0001951829,0.000107798,0.0001391243,0.000272219,0.0002863445,0.0004513898,0.0001474297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183445,"about_ca_system_score_gemma":0.0002528544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004646376,"about_ca_topic_score_gemma":0.0009538598,"domain_scores_codex":[0.9998865,0.00001929316,0.00001716831,0.00002848711,0.00002920255,0.00001929534],"domain_scores_gemma":[0.9999139,0.00001310116,0.00002124512,0.00001322042,0.0000149517,0.00002366364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008406801,0.00001902097,0.000162373,0.00005191148,0.000004760479,0.00005354614,0.00001200127,0.0000451408,0.9948919,0.0002005509,0.00001919536,0.004455605],"study_design_scores_gemma":[0.00001145746,0.0003718778,0.002900804,0.000008232298,0.00002065969,0.0002862361,0.00002777137,0.0005878232,0.9915216,0.0001401618,0.004119784,0.000003576982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983775,0.005664355,0.006066293,0.0001658118,0.00007299089,0.00005332352,0.0002767772,0.0002969768,0.003628545],"genre_scores_gemma":[0.9919543,0.002155458,0.00289883,0.0000625255,0.00001472994,0.00003290968,0.0002679822,0.00002559462,0.002587701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008670547,"threshold_uncertainty_score":0.00290066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004239214472321596,"score_gpt":0.2315720863277303,"score_spread":0.2273328718554087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}