{"id":"W1998566517","doi":"10.1002/stem.1368","title":"Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers","year":2013,"lang":"en","type":"article","venue":"Stem Cells","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Korea Research Institute of Bioscience and Biotechnology; Canadian Institutes of Health Research; Korea Research Council of Fundamental Science and Technology","keywords":"Reprogramming; NAD+ kinase; Biology; Induced pluripotent stem cell; Cell biology; Embryonic stem cell; Nicotinamide phosphoribosyltransferase; Stem cell; Intracellular; Somatic cell; Biochemistry; Cell; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006721653,0.0001146469,0.00009309529,0.00002200246,0.0000497673,0.0000375871,0.00007836564,0.00007769772,0.00003263932],"category_scores_gemma":[0.000008966324,0.0001098281,0.00004216795,0.00004003168,0.0000308572,0.000002987041,0.00007582428,0.00004991241,0.00002297139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004921824,"about_ca_system_score_gemma":0.00001457302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003408552,"about_ca_topic_score_gemma":0.000005257408,"domain_scores_codex":[0.9993168,0.0000137599,0.0001252208,0.0002636928,0.00006413177,0.0002164561],"domain_scores_gemma":[0.9995815,0.000007187511,0.00002614005,0.0002344429,0.00002860668,0.000122147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003920321,0.000006556798,0.002440348,0.00004349224,0.00002253105,0.000001622671,0.00009091252,0.0001287109,0.9745797,0.00003572705,0.0009383449,0.02170813],"study_design_scores_gemma":[0.0002734536,0.0001201149,0.002027855,0.00001779371,0.00001201663,0.00001629075,0.000454026,0.0002369851,0.9705766,0.00005051179,0.02596682,0.000247479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925721,0.00285303,0.002970266,0.00004135129,0.000156307,0.0001836766,0.000002801626,0.00002094995,0.001199567],"genre_scores_gemma":[0.9966195,0.0002490646,0.001300503,0.00006169529,0.00007029901,0.00001794361,0.000004165602,0.00001871955,0.00165813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02502847,"threshold_uncertainty_score":0.4478661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004239214472321596,"score_gpt":0.2315720863277303,"score_spread":0.2273328718554087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}