{"id":"W1998571236","doi":"10.1007/s11060-005-9058-0","title":"Technical hurdles in a pilot clinical trial of combined B7-2 and GM-CSF immunogene therapy for glioblastomas and melanomas","year":2006,"lang":"en","type":"article","venue":"Journal of Neuro-Oncology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Foothills Medical Centre; University of Alberta; University of Calgary","funders":"University of Alberta","keywords":"Clinical trial; Medicine; Genetic enhancement; Melanoma; Oncology; Cancer research; Internal medicine; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001822409,0.0002251871,0.001136717,0.000349332,0.0001008023,0.00001321273,0.0002648798,0.0004559231,0.00003325079],"category_scores_gemma":[0.0005322635,0.0001778649,0.0002368624,0.0001435647,0.0007330949,0.0001156049,0.00007769276,0.0006271787,0.000002080847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004577819,"about_ca_system_score_gemma":0.000269671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004859496,"about_ca_topic_score_gemma":0.00004279735,"domain_scores_codex":[0.9964867,0.001177243,0.00171293,0.000238851,0.00005630921,0.0003279782],"domain_scores_gemma":[0.9952977,0.003324715,0.0009847534,0.0002076403,0.0001582981,0.00002693253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2686566,0.001714811,0.001427619,0.000009501758,0.0001248788,0.0000322621,0.00006250966,0.000001241022,0.7053792,0.0002262265,0.0006474219,0.02171779],"study_design_scores_gemma":[0.3413143,0.1856656,0.09169135,0.0001046661,0.0001503657,0.003642968,0.0001636832,0.000006628912,0.1372537,0.00149148,0.2381104,0.0004047601],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811722,0.01576514,0.00009899436,0.001130104,0.001071152,0.0006354306,0.0000108124,0.00001212878,0.0001040062],"genre_scores_gemma":[0.9925473,0.00626481,0.0006433585,0.000269818,0.0001128802,0.00002299212,0.000004990354,0.00002696275,0.0001069206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5681255,"threshold_uncertainty_score":0.7253119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03872949339390012,"score_gpt":0.3380898182160797,"score_spread":0.2993603248221796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}