{"id":"W1998587100","doi":"10.1016/j.neulet.2005.11.055","title":"Imbalance towards inhibition as a substrate of aging-associated cognitive impairment","year":2005,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute on Aging; Michael Smith Health Research BC","keywords":"Neuroscience; Excitatory postsynaptic potential; Inhibitory postsynaptic potential; Cognition; Psychology; Cognitive decline; Cerebral cortex; Hippocampus; Morris water navigation task; Pyramidal cell; Neurotransmission; Audiology; Medicine; Dementia; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003465857,0.0008851633,0.0005968036,0.001008846,0.0002962386,0.0006299125,0.0004092115,0.0004624744,0.001451766],"category_scores_gemma":[0.000950562,0.0001603321,0.0001812981,0.0002574982,0.0006996568,0.0003925596,0.0004625473,0.0007383325,0.0002332748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003587624,"about_ca_system_score_gemma":0.000302627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009881204,"about_ca_topic_score_gemma":0.0006770245,"domain_scores_codex":[0.999826,0.00001897523,0.00001817837,0.00003668653,0.0000600841,0.0000400014],"domain_scores_gemma":[0.9993488,0.00008011985,0.0002674865,0.00008209904,0.00008602485,0.0001354413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00506595,0.0007571364,0.11262,0.0002052769,0.0003252194,0.006515039,0.0005984571,0.0007845645,0.8179071,0.003191158,0.0009826286,0.05104744],"study_design_scores_gemma":[0.000122297,0.001725747,0.9105548,0.00003284602,0.0002799284,0.01012389,0.00034014,0.001677716,0.06505591,0.008010436,0.002043966,0.00003233907],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932324,0.001698885,0.001244092,0.0002327251,0.00004695322,0.00001762446,0.0001905945,0.00007039357,0.003266327],"genre_scores_gemma":[0.9985766,0.0003062298,0.000384194,0.00004983152,0.00003592349,0.00001031375,0.00008845513,0.000009934343,0.0005384746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001451766,"threshold_uncertainty_score":0.004856646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03939744267000785,"score_gpt":0.3359598383174213,"score_spread":0.2965623956474134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}