{"id":"W1998598404","doi":"10.1016/j.immuni.2014.02.013","title":"Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages","year":2014,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":209,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McGill University; Hôtel-Dieu de Québec; Public Health Agency of Canada; Centre hospitalier universitaire de Québec; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Prostaglandin E2 receptor; Interferon; Immunity; Influenza A virus; Innate immune system; Immune system; Prostaglandin E2; Immunology; Interferon type I; Virus; Apoptosis; Virology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242282,0.000318925,0.0004576698,0.0002115434,0.0001592673,0.0003389163,0.0001916541,0.0003277658,0.001714254],"category_scores_gemma":[0.00009920806,0.0001343215,0.0002955457,0.0001349629,0.0002760458,0.0002229064,0.0001718227,0.0009179206,0.0004150664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002302027,"about_ca_system_score_gemma":0.0002734217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001732095,"about_ca_topic_score_gemma":0.0004355797,"domain_scores_codex":[0.9997926,0.00003644922,0.0000145269,0.0000273179,0.00004433625,0.00008468766],"domain_scores_gemma":[0.9999334,0.00001277375,0.000014309,0.00001121933,0.00000939788,0.00001896558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001712012,0.0001758778,0.0002841558,0.00007774791,0.00001490377,0.00007446494,0.00001573781,0.0001565812,0.993305,0.0001891413,0.0001915823,0.00380271],"study_design_scores_gemma":[0.0001693613,0.00102912,0.003326316,0.000007036761,0.00003222111,0.0001256465,0.0000404035,0.0008012626,0.9920366,0.0001218349,0.002304631,0.000005545469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923927,0.002152176,0.002440564,0.0002137668,0.0001381424,0.0000415906,0.000290341,0.0001023663,0.002228344],"genre_scores_gemma":[0.9952202,0.0007254179,0.0008484704,0.0001115225,0.00003568617,0.00005340539,0.0002062838,0.00001107674,0.002787963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714254,"threshold_uncertainty_score":0.005734742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277824192933927,"score_gpt":0.2506734729696176,"score_spread":0.2378952310402783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}