{"id":"W1998598404","doi":"10.1016/j.immuni.2014.02.013","title":"Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages","year":2014,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":209,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; McGill University; Hôtel-Dieu de Québec; Public Health Agency of Canada; Centre hospitalier universitaire de Québec; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Prostaglandin E2 receptor; Interferon; Immunity; Influenza A virus; Innate immune system; Immune system; Prostaglandin E2; Immunology; Interferon type I; Virus; Apoptosis; Virology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006461236,0.0001505156,0.000283927,0.0001573137,0.0001595802,0.00001400912,0.0001010357,0.0002301473,0.00008161335],"category_scores_gemma":[0.0002345223,0.000138227,0.00003797418,0.0002504736,0.0002427668,0.0003852487,0.0001051431,0.0004179782,0.00004178481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003603301,"about_ca_system_score_gemma":0.00002690195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231381,"about_ca_topic_score_gemma":0.00007123272,"domain_scores_codex":[0.9983336,0.0008991584,0.0003768659,0.0001505309,0.00003384682,0.0002059777],"domain_scores_gemma":[0.999323,0.0001288449,0.0001927149,0.0002566314,0.0000924109,0.000006393132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008631623,0.0001132283,0.002201862,0.00004909818,0.00003489705,1.828815e-7,0.00253228,0.000001166942,0.9863646,0.0002049289,0.00005139793,0.007583202],"study_design_scores_gemma":[0.0009996245,0.0006041014,0.06137991,0.0001130691,0.00001469253,0.000005567424,0.0008572436,0.000007238389,0.9349348,0.0004409881,0.0005106069,0.0001321672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976174,0.001005098,0.0001072957,0.00006944554,0.0003823586,0.0002133633,0.000005844218,0.00003575691,0.0005635019],"genre_scores_gemma":[0.9991564,0.0003619396,0.0000607171,0.00001974104,0.000013981,0.00001143661,0.0002008225,0.00001023597,0.0001647983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05917805,"threshold_uncertainty_score":0.5636735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277824192933927,"score_gpt":0.2506734729696176,"score_spread":0.2378952310402783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}