{"id":"W1998660158","doi":"10.1016/j.bmcl.2005.09.049","title":"Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Celiac Association","keywords":"Tetrapeptide; Chemistry; Tripeptide; Dipeptide; Aldehyde; NS3; Dengue virus; Stereochemistry; Protease; Serine protease; Peptide; Enzyme inhibitor; Biochemistry; Enzyme; Dengue fever; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003900742,0.0004933064,0.0009609493,0.0001234202,0.00008023678,0.00001188339,0.0003440993,0.0001847578,0.0008720143],"category_scores_gemma":[0.0003575314,0.0004316297,0.0003192864,0.0004779436,0.0003104763,0.00008015701,0.0000976724,0.0004974697,0.00002284869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926388,"about_ca_system_score_gemma":0.0002694052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002618029,"about_ca_topic_score_gemma":0.00001735921,"domain_scores_codex":[0.9962042,0.00007055813,0.001260131,0.0006822174,0.00119949,0.000583382],"domain_scores_gemma":[0.9977479,0.00009321966,0.0005633606,0.0008722297,0.0001917142,0.0005315978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006604836,0.001712771,0.02056017,0.0005771248,0.0003591334,0.0001572695,0.0006512065,0.000006010087,0.9599915,0.000001041602,0.0128557,0.002467568],"study_design_scores_gemma":[0.007086592,0.000640363,0.01131508,0.0008313501,0.001106431,0.0001016125,0.003243775,0.00003780596,0.9670298,0.000001866175,0.008163482,0.0004419059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938454,0.001063597,0.00001398071,0.003339701,0.0001877411,0.001142096,0.00004313222,0.00007545433,0.0002889115],"genre_scores_gemma":[0.995847,0.00004198978,0.0001034793,0.001276969,0.002395762,0.00005030966,0.00004213184,0.00007388954,0.0001684493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009245085,"threshold_uncertainty_score":0.9998136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009731485689946457,"score_gpt":0.2382307217676368,"score_spread":0.2284992360776903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}