{"id":"W1998660158","doi":"10.1016/j.bmcl.2005.09.049","title":"Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Celiac Association","keywords":"Tetrapeptide; Chemistry; Tripeptide; Dipeptide; Aldehyde; NS3; Dengue virus; Stereochemistry; Protease; Serine protease; Peptide; Enzyme inhibitor; Biochemistry; Enzyme; Dengue fever; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603228,0.0002952098,0.0002935578,0.0001415587,0.00007793766,0.0001074396,0.0002082563,0.0001405235,0.001290106],"category_scores_gemma":[0.0000802158,0.00009817352,0.0002314061,0.0001123927,0.00008605061,0.0002171849,0.0001073652,0.0003057098,0.0002033405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161848,"about_ca_system_score_gemma":0.00007992771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005267097,"about_ca_topic_score_gemma":0.0008351607,"domain_scores_codex":[0.9999574,0.000007782117,0.000002816116,0.000005241225,0.000009480049,0.00001718161],"domain_scores_gemma":[0.9999785,0.000005176104,0.000004406157,0.000001589336,0.000003935805,0.000006374992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001374698,0.0003054919,0.0002728558,0.0002479987,0.00004243744,0.0002503221,0.00005584232,0.003156721,0.9755101,0.0002756389,0.0003435262,0.01816437],"study_design_scores_gemma":[0.0006409225,0.01108617,0.004706564,0.00002464826,0.0001048132,0.0008245594,0.00004008905,0.003159431,0.9698948,0.0001206584,0.009371317,0.00002591678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821147,0.01113965,0.002387766,0.0001291695,0.00004904097,0.00009967646,0.0003644451,0.00004023734,0.003675337],"genre_scores_gemma":[0.9865149,0.008400703,0.001446632,0.0001303177,0.00002565868,0.0000341024,0.0005822011,0.000007924793,0.002857615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290106,"threshold_uncertainty_score":0.004315853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009731485689946457,"score_gpt":0.2382307217676368,"score_spread":0.2284992360776903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}