{"id":"W1998664238","doi":"10.1016/j.clinbiochem.2006.01.023","title":"Frequency of CYP2C9 polymorphisms affecting warfarin metabolism in a large anticoagulant clinic cohort","year":2006,"lang":"en","type":"article","venue":"Clinical Biochemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"CYP2C9; Warfarin; Genotype; Genotyping; Internal medicine; Allele frequency; Allele; Gastroenterology; Genotype frequency; Medicine; Restriction fragment length polymorphism; Cohort; Anticoagulant; Biology; Genetics; Gene; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003795708,0.0003764354,0.0009983884,0.0001139237,0.000110897,0.00001480299,0.0005540504,0.0008937108,0.001398475],"category_scores_gemma":[0.0006242678,0.0003702042,0.0004520395,0.0004170497,0.0004323352,0.00005633815,0.0002390119,0.001521544,0.0001257322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003569099,"about_ca_system_score_gemma":0.000220227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000126659,"about_ca_topic_score_gemma":0.00001513154,"domain_scores_codex":[0.9956518,0.0005847898,0.001915635,0.0007746837,0.0002724637,0.000800651],"domain_scores_gemma":[0.9974508,0.001018438,0.0005756908,0.0005140729,0.0001243094,0.0003166507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001063323,0.001529583,0.6116678,0.00006728424,0.0001418788,0.00007308144,0.00002824749,0.00001355893,0.382554,0.0002633051,0.001235272,0.0023197],"study_design_scores_gemma":[0.005340724,0.00003697635,0.3479518,0.00003777274,0.0004154565,0.00002191937,0.00003683175,0.0004372132,0.6359755,0.001640458,0.007591718,0.0005136006],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982558,0.00608182,0.00005395684,0.0002698478,0.001734373,0.0003807027,0.0001891077,0.00007151054,0.008660649],"genre_scores_gemma":[0.9956563,0.0008533814,0.0004836133,0.0008480094,0.001079661,0.00003090976,0.0000995626,0.00004161729,0.00090698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2637159,"threshold_uncertainty_score":0.999875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08773732555880336,"score_gpt":0.4538236815173983,"score_spread":0.366086355958595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}