{"id":"W1998675546","doi":"10.1074/jbc.m112.403568","title":"Metabolic Inhibition of Sialyl-Lewis X Biosynthesis by 5-Thiofucose Remodels the Cell Surface and Impairs Selectin-Mediated Cell Adhesion","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Selectin; Sialyl-Lewis X; Chemistry; Biochemistry; Fucose; Glycosyltransferase; Cell adhesion; Cancer cell; Biosynthesis; Cell adhesion molecule; Cell; Adhesion; Cell biology; Cancer; Enzyme; Glycoprotein; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008374227,0.0003531099,0.0002029856,0.00009536261,0.00008664742,0.0002234477,0.0001646966,0.0002190098,0.0009167849],"category_scores_gemma":[0.0000765888,0.0001014836,0.0002251262,0.0001011516,0.0001262489,0.0001356327,0.0001308621,0.0004149054,0.0002498525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940656,"about_ca_system_score_gemma":0.0001482306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00079508,"about_ca_topic_score_gemma":0.0007776854,"domain_scores_codex":[0.9998983,0.00001848916,0.000009852305,0.00001545794,0.00002725167,0.00003049878],"domain_scores_gemma":[0.9999443,0.000008979307,0.0000179373,0.000009657113,0.000005271776,0.0000139146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006968161,0.00002462447,0.0000621998,0.00001529215,0.00000354229,0.00002570979,0.000007248654,0.00006072384,0.9989088,0.0000558857,0.0000192823,0.0007471059],"study_design_scores_gemma":[0.00000432667,0.0002955371,0.000703023,0.000001576995,0.000004924701,0.0000585907,0.000007658999,0.0003474935,0.9976563,0.00001006037,0.0009084136,0.000002109691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954759,0.0009996322,0.002003199,0.00006657455,0.00002831516,0.000019268,0.0002456693,0.00006799024,0.001093365],"genre_scores_gemma":[0.9956884,0.0007311619,0.001257694,0.00003536772,0.000004933225,0.00002239943,0.0003251205,0.00001393128,0.001920923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009167849,"threshold_uncertainty_score":0.003066957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155667840747243,"score_gpt":0.2490842514794684,"score_spread":0.2335174674047441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}