{"id":"W1998676146","doi":"10.3390/v6114227","title":"Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding","year":2014,"lang":"en","type":"review","venue":"Viruses","topic":"Hepatitis C virus research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"NS5A; Hepatitis C virus; Virology; Protease inhibitor (pharmacology); Drug resistance; Drug; Potency; Medicine; Biology; Pharmacology; Hepacivirus; Virus; In vitro; Viral load; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008726023,0.0008401243,0.002949558,0.001065566,0.0002439915,0.0001704895,0.0004843712,0.0005843355,0.0001705413],"category_scores_gemma":[0.002604988,0.0005963388,0.0004039989,0.001500571,0.0002131732,0.0002435776,0.0002318991,0.00150568,0.0006602131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110237,"about_ca_system_score_gemma":0.001264065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005870917,"about_ca_topic_score_gemma":0.004304178,"domain_scores_codex":[0.9946806,0.0008618773,0.001167854,0.001012509,0.001406772,0.0008704207],"domain_scores_gemma":[0.9963043,0.001073092,0.0007586987,0.001060828,0.0003294924,0.0004735351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001468951,0.0003698965,0.01057866,0.05045743,0.00145448,0.0008848218,0.0008016428,1.66832e-7,0.0000319978,0.00004690635,0.02178387,0.9134432],"study_design_scores_gemma":[0.0006645779,0.0001715825,0.00006461455,0.1000894,0.0007277257,0.000005489232,0.00001414059,0.00000191026,0.000112893,0.000003197604,0.897566,0.000578454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002077735,0.9899665,0.00001734888,0.0001346122,0.0002737073,0.002626098,0.0002350073,0.0003956238,0.00427338],"genre_scores_gemma":[0.0009416005,0.9921468,0.0001496277,0.0004258637,0.0005614266,0.0004674158,0.0005716619,0.0003424021,0.004393203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9128648,"threshold_uncertainty_score":0.9996488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07166580756219074,"score_gpt":0.3619286461692847,"score_spread":0.2902628386070939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}