{"id":"W1998676146","doi":"10.3390/v6114227","title":"Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding","year":2014,"lang":"en","type":"review","venue":"Viruses","topic":"Hepatitis C virus research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"NS5A; Hepatitis C virus; Virology; Protease inhibitor (pharmacology); Drug resistance; Drug; Potency; Medicine; Biology; Pharmacology; Hepacivirus; Virus; In vitro; Viral load; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000441206,0.0004381216,0.0009453912,0.002310703,0.0001930815,0.0008736253,0.000441462,0.0005981626,0.003782551],"category_scores_gemma":[0.0008138217,0.0001772051,0.000554846,0.002221795,0.0003636064,0.0008261065,0.0004411514,0.0008087118,0.00130081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005005854,"about_ca_system_score_gemma":0.0009080972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214875,"about_ca_topic_score_gemma":0.002089213,"domain_scores_codex":[0.9997353,0.00004219541,0.00005417849,0.00005225217,0.00008992087,0.000026045],"domain_scores_gemma":[0.9996087,0.0001805578,0.00007923377,0.00001346403,0.0001015665,0.00001649306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006313525,0.00002814657,0.000574791,0.01942082,0.00009775707,0.0002508796,0.00008701595,0.0002043441,0.002313086,0.002408579,0.01068332,0.9638681],"study_design_scores_gemma":[0.00001337736,0.0001348366,0.003988625,0.009045416,0.0003530097,0.005656756,0.0001922052,0.0001055258,0.00151476,0.001758246,0.9772056,0.00003166688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003326372,0.9980214,0.0001037554,0.0002226794,0.0000758399,0.000003179033,0.00003694513,0.000005375339,0.001198166],"genre_scores_gemma":[0.001658558,0.9975203,0.0001496498,0.0001154708,0.00005597299,0.000002806783,0.00004018938,0.000001398249,0.0004556239],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003782551,"threshold_uncertainty_score":0.01265389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07166580756219074,"score_gpt":0.3619286461692847,"score_spread":0.2902628386070939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}