{"id":"W1998682097","doi":"10.1074/jbc.m700906200","title":"RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":758,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Ribosomal s6 kinase; Ribosomal protein s6; P70-S6 Kinase 1; Cell biology; PI3K/AKT/mTOR pathway; Biology; Phosphorylation; MAPK/ERK pathway; Phosphorylation cascade; Signal transduction; Protein kinase A; Kinase; Eukaryotic Small Ribosomal Subunit; Molecular biology; Chemistry; Translation (biology); Protein phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007954784,0.0002310535,0.0002710964,0.0000296987,0.00008678193,0.00003939308,0.000176607,0.0004413958,0.00008080275],"category_scores_gemma":[0.0001162565,0.0001836069,0.0001444976,0.00008043287,0.0001167436,0.00001311966,0.00003589041,0.0003210213,0.000001780641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005058504,"about_ca_system_score_gemma":0.0000467008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002050795,"about_ca_topic_score_gemma":9.08611e-7,"domain_scores_codex":[0.9984747,0.00004714961,0.0006035285,0.0003286111,0.0002503205,0.0002957005],"domain_scores_gemma":[0.9990047,0.00006199992,0.0004141344,0.0001492038,0.0002060757,0.0001638992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006023211,0.00009070378,0.002852904,0.00002864893,0.00004030561,0.00002651108,0.00003214189,0.0001988342,0.9888637,0.000001849693,0.00002802626,0.007234035],"study_design_scores_gemma":[0.000835482,0.0005541608,0.001679367,0.00006735908,0.00002088972,0.0001254814,0.00003376089,0.00007276207,0.9947364,0.0002451487,0.001390921,0.0002382992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834345,0.006623097,0.009454764,0.00010334,0.00006944082,0.0001699693,0.00001001828,0.0000138188,0.0001210553],"genre_scores_gemma":[0.9951996,0.0001435531,0.003737109,0.00005333758,0.0007467821,0.000003173418,0.00004642216,0.0000160068,0.00005406869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01176505,"threshold_uncertainty_score":0.7487273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02136855821073564,"score_gpt":0.2553617892331512,"score_spread":0.2339932310224156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}