{"id":"W1998708130","doi":"10.1002/ijc.23703","title":"Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma—Epigenetic downregulation of caspases","year":2008,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"DNA methylation; Biology; Cancer research; DNMT1; Stromal cell; Downregulation and upregulation; Gene silencing; Epigenetics; Caspase; Apoptosis; Carcinogenesis; Programmed cell death; Gene expression; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002194672,0.0002262742,0.0002218534,0.0001521975,0.0001330345,0.0002440189,0.00009853179,0.0002597289,0.0008216904],"category_scores_gemma":[0.00009079123,0.00006907966,0.0002257734,0.000132011,0.0001847895,0.0001857703,0.0001858412,0.0004269824,0.0001664035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234174,"about_ca_system_score_gemma":0.0001052491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001503333,"about_ca_topic_score_gemma":0.0002242929,"domain_scores_codex":[0.9998853,0.00002866074,0.00001460958,0.00002613326,0.00002084038,0.0000243216],"domain_scores_gemma":[0.9998944,0.00001572418,0.00003362075,0.00001661843,0.00002000036,0.00001960157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007190928,0.0000113611,0.0005510438,0.00005250204,0.000004953939,0.00005813985,0.00001618538,0.00002088678,0.9975517,0.00005050512,0.00001280761,0.001597818],"study_design_scores_gemma":[0.00001357612,0.0003158051,0.01409571,0.000009303038,0.00002816799,0.0005874473,0.0000537442,0.0004267351,0.9822264,0.00007285557,0.002165389,0.000004832842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865549,0.009239156,0.002951846,0.0002015283,0.00002520759,0.00002920335,0.0001844949,0.00004782619,0.0007659135],"genre_scores_gemma":[0.9949281,0.002310195,0.00161057,0.00006061675,0.00001718403,0.00002290696,0.0001478354,0.00000656668,0.0008959532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008216904,"threshold_uncertainty_score":0.002748787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123478887666847,"score_gpt":0.3382711026618211,"score_spread":0.3170363137851526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}