{"id":"W1998708130","doi":"10.1002/ijc.23703","title":"Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma—Epigenetic downregulation of caspases","year":2008,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"DNA methylation; Biology; Cancer research; DNMT1; Stromal cell; Downregulation and upregulation; Gene silencing; Epigenetics; Caspase; Apoptosis; Carcinogenesis; Programmed cell death; Gene expression; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181923,0.000079197,0.0005261275,0.00035164,0.000008753583,0.000001312107,0.0001621355,0.00005844225,0.000178691],"category_scores_gemma":[0.0001889313,0.0000656276,0.0001060701,0.0001663279,0.0002100159,0.00007046668,0.00002492798,0.0001181561,5.331845e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001639131,"about_ca_system_score_gemma":0.000660343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005898578,"about_ca_topic_score_gemma":0.0001291977,"domain_scores_codex":[0.9983155,0.00004702338,0.000782404,0.00007930475,0.0006669398,0.0001088783],"domain_scores_gemma":[0.9979025,0.0001575623,0.0006718489,0.0001012638,0.001110189,0.00005668878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001832609,0.0001971433,0.8180029,0.0001021713,0.0002722283,0.00006036148,0.0006181615,0.0002642889,0.1767005,0.0001284413,0.00006530996,0.001755784],"study_design_scores_gemma":[0.002124772,0.000348251,0.8985453,0.000650493,0.00008907948,0.0001272197,0.0001065312,0.0004977552,0.09701505,0.0003991105,0.00005609737,0.00004030501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940504,0.00452773,0.00007837563,0.0002495787,0.00006539245,0.0001081212,0.00001831954,0.000001249645,0.0009007617],"genre_scores_gemma":[0.997411,0.001383255,0.0009040072,0.00002004453,0.0001097692,0.000005040691,0.000002827478,0.00000796201,0.0001561241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08054239,"threshold_uncertainty_score":0.2676215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123478887666847,"score_gpt":0.3382711026618211,"score_spread":0.3170363137851526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}