{"id":"W1998763810","doi":"10.1038/ncb1231","title":"Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control","year":2005,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":378,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Novartis Foundation","keywords":"P70-S6 Kinase 1; PI3K/AKT/mTOR pathway; Cell biology; Protein kinase B; Biology; Skeletal muscle; Effector; RPTOR; Myocyte; Cell cycle; Cell growth; mTORC1; Myogenesis; Cell; Phosphorylation; Signal transduction; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106608,0.0004675203,0.0005568704,0.000549086,0.0002682861,0.0006050109,0.0004904091,0.0003589843,0.002001488],"category_scores_gemma":[0.0002012195,0.0004359966,0.0004289479,0.0002315252,0.0006392493,0.0005109132,0.000354307,0.001195973,0.0008763857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004926228,"about_ca_system_score_gemma":0.0002221385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007538279,"about_ca_topic_score_gemma":0.001338483,"domain_scores_codex":[0.9997973,0.00001921885,0.00002396282,0.0000525808,0.00006961905,0.00003733259],"domain_scores_gemma":[0.9997472,0.0000387571,0.00006745591,0.00004116357,0.00002550866,0.00007993469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175474,0.000007517377,0.0001724522,0.00001554172,0.000003237358,0.0000226066,0.000007559858,0.00003146119,0.998958,0.0001648909,0.00002974499,0.0004695554],"study_design_scores_gemma":[0.00003200109,0.0001280974,0.02912647,0.00000713573,0.000020274,0.0005493032,0.00006087908,0.001278297,0.9668369,0.0002457146,0.001704674,0.00001010848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950646,0.00117318,0.001798178,0.0002478231,0.00002958617,0.00001136965,0.0005069713,0.00009187224,0.001076463],"genre_scores_gemma":[0.993175,0.0008925489,0.002171158,0.000171679,0.00002243769,0.00003718322,0.0009673731,0.000100122,0.002462511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002001488,"threshold_uncertainty_score":0.006695688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001740425637206591,"score_gpt":0.2164677116841257,"score_spread":0.2147272860469191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}