{"id":"W1998763810","doi":"10.1038/ncb1231","title":"Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control","year":2005,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":378,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Novartis Foundation","keywords":"P70-S6 Kinase 1; PI3K/AKT/mTOR pathway; Cell biology; Protein kinase B; Biology; Skeletal muscle; Effector; RPTOR; Myocyte; Cell cycle; Cell growth; mTORC1; Myogenesis; Cell; Phosphorylation; Signal transduction; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742787,0.0002389049,0.0003490143,0.00002683418,0.00008139399,0.000004817677,0.0001974102,0.0008277994,0.00003460152],"category_scores_gemma":[0.000139989,0.0002047017,0.0001890826,0.00005170739,0.0002456802,0.000003807941,0.00007033477,0.0002332606,0.00000562738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007678982,"about_ca_system_score_gemma":0.00003290741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007378047,"about_ca_topic_score_gemma":0.00001503462,"domain_scores_codex":[0.9986989,0.0001419509,0.000257067,0.0004983535,0.00004493733,0.0003587132],"domain_scores_gemma":[0.9991028,0.0002541475,0.000169557,0.0002947247,0.00008510593,0.00009364189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003063189,0.0001359056,0.0009959849,0.0001029871,0.00003412428,3.508594e-7,0.00001484495,0.00002799226,0.9948705,0.00007880527,0.001426253,0.002005919],"study_design_scores_gemma":[0.005790097,0.002384644,0.02031897,0.000009392277,0.00010805,0.000001598523,0.00002683505,0.0001178783,0.8687463,0.0007087368,0.1012665,0.0005209468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925982,0.004744868,0.0003814831,0.0001214434,0.0003118272,0.0004922087,0.0001650075,0.00001350256,0.001171459],"genre_scores_gemma":[0.9975859,0.0001471536,0.0007065512,0.0006939773,0.0003944453,0.00004378812,0.0001610474,0.0000249826,0.0002421529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1261242,"threshold_uncertainty_score":0.8347492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001740425637206591,"score_gpt":0.2164677116841257,"score_spread":0.2147272860469191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}