{"id":"W1998766540","doi":"10.1021/bi900606y","title":"Transmembrane Topology of the Mammalian Slc11a2 Iron Transporter","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Membrane topology; Transmembrane protein; Transmembrane domain; Extracellular; C-terminus; Epitope; Topology (electrical circuits); Membrane protein; Transporter; Biology; Membrane transport protein; Transport protein; Chemistry; Peptide sequence; Cell biology; Amino acid; N-terminus; Intracellular; Biochemistry; Membrane; Gene; Antigen; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004477186,0.00009403622,0.000166193,0.00001290087,0.00002379278,0.00000165333,0.0001058061,0.0001196379,0.0003518413],"category_scores_gemma":[0.00001014221,0.00006391036,0.000127188,0.00007832483,0.0001127796,0.00001160466,0.000003018013,0.0001018466,0.000004138592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006513239,"about_ca_system_score_gemma":0.00005293998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001033362,"about_ca_topic_score_gemma":8.621129e-7,"domain_scores_codex":[0.9994093,0.000008005408,0.0001649758,0.0001412198,0.0001259089,0.0001506127],"domain_scores_gemma":[0.9995688,0.000004785676,0.00003815097,0.0003102342,0.00001967075,0.00005833217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008551931,0.0001676464,0.004267609,0.0002455078,0.000005153908,0.000006063186,0.0001848574,8.568455e-7,0.987504,0.0001838056,0.001210425,0.006138532],"study_design_scores_gemma":[0.001262184,0.00005116613,0.12467,0.00002565026,0.0001038059,0.00003061993,0.0001274555,0.000001509222,0.8710873,0.00008469248,0.00246809,0.0000875334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777066,0.0007852034,0.00002630031,0.00421361,0.00008251185,0.00009674513,0.00001081987,0.0000175973,0.01706062],"genre_scores_gemma":[0.995988,0.00003861308,0.0001178273,0.001019738,0.00009382325,0.00000162304,0.00001674047,0.000006286046,0.00271731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1204024,"threshold_uncertainty_score":0.3852416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006134191233193196,"score_gpt":0.233239027275553,"score_spread":0.2271048360423598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}