{"id":"W1998766540","doi":"10.1021/bi900606y","title":"Transmembrane Topology of the Mammalian Slc11a2 Iron Transporter","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Membrane topology; Transmembrane protein; Transmembrane domain; Extracellular; C-terminus; Epitope; Topology (electrical circuits); Membrane protein; Transporter; Biology; Membrane transport protein; Transport protein; Chemistry; Peptide sequence; Cell biology; Amino acid; N-terminus; Intracellular; Biochemistry; Membrane; Gene; Antigen; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005787982,0.0001336823,0.00009052634,0.0001409294,0.0001503667,0.0002924201,0.00006993397,0.0002303859,0.0006471691],"category_scores_gemma":[0.00009804357,0.00006603747,0.0001167384,0.0001925695,0.00008374491,0.0001633653,0.00007276789,0.0001465356,0.0003489765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885294,"about_ca_system_score_gemma":0.0001232473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009061227,"about_ca_topic_score_gemma":0.0007595232,"domain_scores_codex":[0.9999456,0.000007594314,0.000004713937,0.00001682886,0.0000176546,0.000007546455],"domain_scores_gemma":[0.999971,0.000003600638,0.000007337866,0.000002038759,0.000008154882,0.000007857366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008792555,0.000005419573,0.0009522639,0.00002432011,0.000003994519,0.0001209343,0.00002554449,0.0001839668,0.9972768,0.0002624008,0.0001074232,0.0009489487],"study_design_scores_gemma":[0.00005962995,0.0002910541,0.1077285,0.00003758247,0.00006226625,0.004349371,0.0003213007,0.01722726,0.8305419,0.000797714,0.03852749,0.00005581803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935693,0.0009994647,0.002378566,0.0001093047,0.00001353731,0.00000779988,0.001092818,0.00004003135,0.001789142],"genre_scores_gemma":[0.9926873,0.0008119701,0.001965899,0.00005392603,0.00001041879,0.00001460075,0.002890333,0.00001102459,0.001554469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009061227,"threshold_uncertainty_score":0.00216496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006134191233193196,"score_gpt":0.233239027275553,"score_spread":0.2271048360423598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}