{"id":"W1998858758","doi":"10.1016/j.pbiomolbio.2008.05.004","title":"Conformational stability and folding mechanisms of dimeric proteins","year":2008,"lang":"en","type":"review","venue":"Progress in Biophysics and Molecular Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Protein folding; Folding (DSP implementation); Chemistry; Denaturation (fissile materials); Protein stability; Protein subunit; Monomer; Biophysics; Protein structure; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001103221,0.0003429124,0.0008066538,0.00009219169,0.00004688239,0.00001145687,0.0001733302,0.0004776751,0.000001522726],"category_scores_gemma":[0.00002467704,0.0002884547,0.0001533137,0.0001372418,0.0004773254,0.000004197903,0.0003185941,0.0001740393,2.823176e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001169121,"about_ca_system_score_gemma":0.0001370855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006185896,"about_ca_topic_score_gemma":0.000001822953,"domain_scores_codex":[0.9986197,0.0001084883,0.0004547961,0.0004813842,0.00008162567,0.0002540251],"domain_scores_gemma":[0.999239,0.00001494096,0.0003226227,0.0002994091,0.00006176264,0.0000622834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000281892,0.00007407139,0.0001435015,0.003382,0.0001926289,0.000008499651,0.00003313097,2.074168e-7,0.01077502,0.02763254,0.000002530532,0.9577277],"study_design_scores_gemma":[0.004264204,0.005109889,0.0002133852,0.006033719,0.0009694804,0.001110204,0.0001123388,0.0002548628,0.1040783,0.08961417,0.7827151,0.005524397],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004302097,0.9875449,0.007057173,0.000007259974,0.00007542067,0.0008563094,0.0001014057,0.000006514193,0.00004890172],"genre_scores_gemma":[0.02662945,0.9679878,0.004515523,0.00002682893,0.00003781239,0.0001865285,0.0005854316,0.00002868498,0.000001920469],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9522033,"threshold_uncertainty_score":0.9999568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323643256572668,"score_gpt":0.2972702168800653,"score_spread":0.2840337843143386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}