{"id":"W1998914928","doi":"10.1016/j.ygeno.2009.12.001","title":"EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines","year":2009,"lang":"en","type":"article","venue":"Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Biology; Epigenetics; Methylation; CpG site; Methylated DNA immunoprecipitation; Genomic imprinting; Differentially methylated regions; Molecular biology; Illumina Methylation Assay; Lymphoblast; Genetics; Cell culture; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740534,0.0001125127,0.00009406948,0.00005418893,0.0000739255,0.00002960119,0.00005990545,0.0001235635,0.000002232304],"category_scores_gemma":[0.000008005807,0.0001173564,0.00003402502,0.00005256059,0.00001849674,0.000008339653,0.00001494507,0.00004542404,0.000001515807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002789309,"about_ca_system_score_gemma":0.00002212088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009949218,"about_ca_topic_score_gemma":0.00004808635,"domain_scores_codex":[0.9993365,0.0000345172,0.0002294017,0.0001989388,0.00005608643,0.0001445198],"domain_scores_gemma":[0.9997259,0.000006121215,0.00006686,0.0001254845,0.00003312904,0.00004250905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001616249,0.00003437446,0.0004906665,0.00001858501,0.000001415543,2.269801e-7,0.0004819043,0.001592119,0.992149,0.00002715799,0.000003089053,0.005185332],"study_design_scores_gemma":[0.0005750439,0.0001604399,0.008005039,0.000004145878,0.000007715366,6.160192e-7,0.0001227012,0.0003684608,0.9872266,0.0006522708,0.002731028,0.000145955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934224,0.001779755,0.002954671,0.00005191148,0.00003636953,0.0001619545,0.000004597048,0.000007756466,0.00158058],"genre_scores_gemma":[0.9968241,0.001356998,0.001484598,0.0000415112,0.000087131,0.00000423121,0.0001111383,0.00001048915,0.00007977165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007514373,"threshold_uncertainty_score":0.4785655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008146867151310907,"score_gpt":0.2327604137676111,"score_spread":0.2246135466163002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}