{"id":"W1998914928","doi":"10.1016/j.ygeno.2009.12.001","title":"EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines","year":2009,"lang":"en","type":"article","venue":"Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Biology; Epigenetics; Methylation; CpG site; Methylated DNA immunoprecipitation; Genomic imprinting; Differentially methylated regions; Molecular biology; Illumina Methylation Assay; Lymphoblast; Genetics; Cell culture; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004886048,0.0002518895,0.0003502701,0.0004316153,0.0003400595,0.0005218208,0.0003001527,0.0002560096,0.002586813],"category_scores_gemma":[0.0004718573,0.0002358147,0.0002735568,0.0004375644,0.0002789613,0.0002335599,0.0003600169,0.0006761405,0.00114588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002908788,"about_ca_system_score_gemma":0.0002615736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001721412,"about_ca_topic_score_gemma":0.00173761,"domain_scores_codex":[0.9996061,0.0001184441,0.00005706446,0.00006974116,0.00008488854,0.00006384355],"domain_scores_gemma":[0.9996278,0.0001621638,0.00003583649,0.000105206,0.00003735492,0.00003156797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001329249,0.00001761526,0.0002933069,0.0000138484,0.000004571872,0.00004733535,0.00007062121,0.00002864159,0.9984352,0.0001369491,0.00004403308,0.0007748877],"study_design_scores_gemma":[0.000008724967,0.00007237594,0.001950563,0.000002214204,0.00001205506,0.0001464175,0.00004318791,0.0002049081,0.9954752,0.00005534648,0.002025329,0.000003562003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790996,0.001375372,0.01511047,0.0001493269,0.00005011464,0.00007937999,0.001293894,0.0003466548,0.002495356],"genre_scores_gemma":[0.9835356,0.0008938431,0.006889972,0.00005507225,0.00001637673,0.0001118691,0.003123193,0.000126817,0.00524709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002586813,"threshold_uncertainty_score":0.00865376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008146867151310907,"score_gpt":0.2327604137676111,"score_spread":0.2246135466163002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}