{"id":"W1998923570","doi":"10.1515/bc.2006.130","title":"Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Helminth infection and control","field":"Veterinary","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Fasciola hepatica; Enzyme; Biochemistry; Recombinant DNA; Biology; Proteases; Cleavage (geology); Cathepsin B; Endopeptidase; Pichia pastoris; Enzyme assay; Cathepsin; Chemistry; Helminths; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341829,0.0002087093,0.0001860366,0.000138173,0.000130781,0.0003356887,0.0001325501,0.0002791516,0.0003516632],"category_scores_gemma":[0.0002518455,0.0001223455,0.0001723759,0.0002015296,0.000182128,0.0002225273,0.0001032418,0.0004350923,0.0001904366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004596633,"about_ca_system_score_gemma":0.0001833736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244892,"about_ca_topic_score_gemma":0.001073822,"domain_scores_codex":[0.9999,0.00001995211,0.00001371004,0.00002189461,0.00002106482,0.00002330538],"domain_scores_gemma":[0.9999043,0.00002538036,0.00002270904,0.00001428397,0.00001117769,0.00002206689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028077,0.00002716349,0.0002738238,0.00002552076,0.000002891821,0.00004930339,0.00001751023,0.00009415405,0.9987059,0.00007878066,0.00002081621,0.0006013034],"study_design_scores_gemma":[0.00002124875,0.0001678097,0.004505772,0.000004807624,0.00001218642,0.0003232982,0.00003526601,0.001270394,0.9922845,0.00004442609,0.001325349,0.000005039173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973225,0.0004558349,0.001442035,0.0001081483,0.00001053956,0.00001192803,0.0002604219,0.00001581493,0.0003726833],"genre_scores_gemma":[0.9944512,0.0003268406,0.002920827,0.00003644633,0.000005334487,0.00001238236,0.001047668,0.0000108141,0.001188446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244892,"threshold_uncertainty_score":0.003335059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323852879600935,"score_gpt":0.2821644296851828,"score_spread":0.2497791417250893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}