{"id":"W1998952700","doi":"10.1016/j.jmb.2009.01.066","title":"Application of Methyl-TROSY NMR to Test Allosteric Models Describing Effects of Nucleotide Binding to Aspartate Transcarbamoylase","year":2009,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Aspartate carbamoyltransferase; Allosteric regulation; Chemistry; Allosteric enzyme; Nucleotide; Stereochemistry; Binding site; Nuclear magnetic resonance spectroscopy; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004047334,0.0002002968,0.0004370921,0.000239975,0.00002720954,0.000008854053,0.0004385404,0.0002065143,0.000001119032],"category_scores_gemma":[0.0003897843,0.0001775641,0.0002788646,0.0003158103,0.00005996307,0.000006583588,0.00009350359,0.0001704306,0.00000303279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002166394,"about_ca_system_score_gemma":0.00007493717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001198857,"about_ca_topic_score_gemma":0.000002611301,"domain_scores_codex":[0.9983748,0.0001471097,0.0006031846,0.0003093032,0.0002178725,0.0003477218],"domain_scores_gemma":[0.9987271,0.00004798451,0.0002870293,0.0003273711,0.0003378464,0.0002726878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002838354,0.0002319366,0.0001052738,0.00004957515,0.00008952051,0.00001812896,0.00005136452,0.0009180533,0.9890855,0.0001776633,0.0000665776,0.008922586],"study_design_scores_gemma":[0.0006698387,0.004048659,0.000150053,0.00007870706,0.00005563756,0.00003769786,0.00001446713,0.000126297,0.9937572,0.0004435693,0.0004502513,0.0001675647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8028708,0.0007087262,0.1955639,0.0004458153,0.00004098997,0.0003079918,0.00001217648,0.000005879395,0.00004371622],"genre_scores_gemma":[0.9871097,0.00008735903,0.01215784,0.0005184641,0.00005858282,0.000009480474,0.00001572555,0.00003381853,0.000009068859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1842388,"threshold_uncertainty_score":0.7240853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01436622450890491,"score_gpt":0.2900779582548365,"score_spread":0.2757117337459316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}