{"id":"W1998975327","doi":"10.1074/jbc.m113.526970","title":"Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Simon Fraser University","funders":"Canadian Institutes of Health Research","keywords":"Phosphocholine; Helix (gastropod); Chemistry; Active site; Amphiphile; Stereochemistry; Biochemistry; Biophysics; Phosphatidylcholine; Membrane; Enzyme; Phospholipid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006953855,0.000208608,0.000154352,0.0000743146,0.0002852872,0.0001893302,0.0002885244,0.0003664391,0.0007033944],"category_scores_gemma":[0.0001582762,0.0001229775,0.0001664308,0.00008391614,0.0002313507,0.0001850176,0.0002018482,0.0005326322,0.0002449123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004071853,"about_ca_system_score_gemma":0.0003682126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253666,"about_ca_topic_score_gemma":0.0009172488,"domain_scores_codex":[0.9999613,0.000006235516,0.000003110712,0.000007762105,0.0000134358,0.000008224674],"domain_scores_gemma":[0.9999231,0.00001296988,0.00002495189,0.000004013474,0.00001013941,0.00002487522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003558233,0.0001232333,0.001888085,0.0001067862,0.00001917926,0.000855145,0.0001006586,0.005509999,0.9859407,0.00184497,0.0003566011,0.002898906],"study_design_scores_gemma":[0.0004872609,0.001182768,0.06322308,0.00009700493,0.0001285761,0.002576406,0.0005219257,0.2132748,0.7036313,0.004513481,0.01027892,0.00008447013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950252,0.0003393164,0.003022727,0.0001276377,0.00002299112,0.00002580882,0.00008011928,0.00007684075,0.00127928],"genre_scores_gemma":[0.9982175,0.0001528984,0.001006011,0.00005046721,0.000005987391,0.00001440108,0.000188696,0.000009575938,0.0003545053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253666,"threshold_uncertainty_score":0.002954364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02040782606651618,"score_gpt":0.2649992409476055,"score_spread":0.2445914148810893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}