{"id":"W1999046457","doi":"10.1126/science.1092132","title":"The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?","year":2003,"lang":"en","type":"review","venue":"Science","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Institute on Aging","keywords":"Disease; Phenotype; Biology; Genetics; Penetrant (biochemical); Gene; Schizophrenia (object-oriented programming); Candidate gene; Bipolar disorder; Age of onset; Etiology; Neuroscience; Medicine; Psychiatry; Cognition; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00104145,0.001157968,0.001802333,0.001361093,0.000306145,0.001420745,0.001468883,0.002286861,0.002933389],"category_scores_gemma":[0.001125394,0.0002678707,0.0003176232,0.002278367,0.00188096,0.003084183,0.0008079851,0.002336797,0.002848165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008835037,"about_ca_system_score_gemma":0.001051392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292785,"about_ca_topic_score_gemma":0.002174967,"domain_scores_codex":[0.9997783,0.00006567764,0.00003101986,0.00003699839,0.00006966927,0.00001830731],"domain_scores_gemma":[0.9992896,0.0003538365,0.00006196687,0.00003521639,0.0001842204,0.00007515202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009893007,0.00003953108,0.0007453404,0.005552907,0.00008943633,0.001407221,0.0001551186,0.0003527585,0.001489556,0.01173384,0.07064654,0.907689],"study_design_scores_gemma":[0.0000217216,0.00005387896,0.001627836,0.002307888,0.00006585605,0.007892833,0.0002577747,0.00009194448,0.0002227391,0.01544475,0.971991,0.00002173302],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008341546,0.9972791,0.0002383534,0.001352132,0.0003217807,0.00000118467,0.000005496606,0.000007219154,0.0007113182],"genre_scores_gemma":[0.0009078541,0.996293,0.0003715945,0.0008321065,0.0007204004,0.000003392045,0.00001428369,0.000002617265,0.0008547032],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002933389,"threshold_uncertainty_score":0.00981313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138374377408174,"score_gpt":0.294727255811686,"score_spread":0.2733435120376043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}