{"id":"W1999098193","doi":"10.1002/stem.1017","title":"In Vivo Generation of Neural Tumors from Neoplastic Pluripotent Stem Cells Models Early Human Pediatric Brain Tumor Formation","year":2011,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Manitoba","funders":"","keywords":"Biology; Medulloblastoma; Embryonic stem cell; Neurosphere; Neuroectoderm; Induced pluripotent stem cell; Neural stem cell; Stem cell; Cancer research; Glioma; Cell biology; Pathology; Adult stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577965,0.0002965115,0.00013346,0.0002299939,0.0001162877,0.0001658744,0.0001978774,0.0002175768,0.00170574],"category_scores_gemma":[0.000104157,0.0001305327,0.0001569919,0.0001227758,0.0002021323,0.0001485913,0.0001960076,0.0004844049,0.0003100022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201194,"about_ca_system_score_gemma":0.0002522331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004314752,"about_ca_topic_score_gemma":0.0007741795,"domain_scores_codex":[0.9998692,0.00002418022,0.00001618208,0.00002792903,0.00004913777,0.00001327437],"domain_scores_gemma":[0.9999179,0.00002197718,0.0000232236,0.00001550671,0.000006413069,0.00001497807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009636697,0.00008732031,0.0003933848,0.00005661163,0.00000675588,0.0001622148,0.00005890272,0.0005024769,0.9954146,0.0008646934,0.00008125188,0.002275431],"study_design_scores_gemma":[0.00001696776,0.0004349112,0.001364315,0.00000659032,0.00001681681,0.0004496148,0.0000229598,0.001500341,0.9920875,0.0001047352,0.003992547,0.000002752517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726418,0.0006624935,0.02165109,0.00006021413,0.00004284689,0.0003637605,0.0009917355,0.000163348,0.003422682],"genre_scores_gemma":[0.9793791,0.001085597,0.01415884,0.00002307598,0.000007779446,0.0002820168,0.001213634,0.00003763131,0.00381222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170574,"threshold_uncertainty_score":0.005706251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566783074268778,"score_gpt":0.2376787470819723,"score_spread":0.2020109163392845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}