{"id":"W1999104671","doi":"10.1523/jneurosci.6348-09.2010","title":"Impaired Ganglioside Metabolism in Huntington's Disease and Neuroprotective Role of GM1","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Alberta Heritage Foundation for Medical Research; Huntington Society of Canada","keywords":"Huntingtin; Huntington's disease; Neuroprotection; Ganglioside; Apoptosis; Biology; Pathogenesis; Mutant; Huntingtin Protein; Neuroscience; Cell biology; Endocrinology; Internal medicine; Cancer research; Disease; Immunology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009288764,0.0002514856,0.0001837303,0.0002039243,0.00009278309,0.0001099075,0.0001005368,0.0002043412,0.0004783932],"category_scores_gemma":[0.00006577978,0.00007595508,0.00007659969,0.0000846551,0.0002789786,0.0001558034,0.0001286257,0.000219858,0.0001100575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284479,"about_ca_system_score_gemma":0.000123109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005764147,"about_ca_topic_score_gemma":0.0007120791,"domain_scores_codex":[0.9999788,0.000006316666,0.000002386513,0.000003670667,0.000004086116,0.000004756285],"domain_scores_gemma":[0.9999806,0.000002501082,0.000005146955,0.000001826868,0.00000211019,0.000007825104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00170051,0.00007312706,0.00192772,0.0001458575,0.00002055299,0.0007723649,0.00005053922,0.0002168004,0.9867556,0.0003325292,0.000120499,0.007883876],"study_design_scores_gemma":[0.0004052589,0.002726275,0.1259595,0.00008173689,0.0001663969,0.005490062,0.0001894309,0.001543012,0.8533812,0.002343046,0.007692954,0.00002104974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917265,0.006892074,0.000228617,0.0001207411,0.000009965135,0.000009156181,0.00009609813,0.0000122918,0.0009045267],"genre_scores_gemma":[0.9957446,0.003020106,0.000297195,0.00005593798,0.000008332011,0.00001028134,0.0001581739,0.000002593865,0.0007028838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005764147,"threshold_uncertainty_score":0.001657546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456605709284218,"score_gpt":0.2541768241595981,"score_spread":0.2396107670667559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}