{"id":"W1999109674","doi":"10.1073/pnas.0500646102","title":"Identifying photoreceptors in blind eyes caused by <i>RPE65</i> mutations: Prerequisite for human gene therapy success","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; Macula Vision Research Foundation; Research to Prevent Blindness; F. M. Kirby Foundation; National Eye Institute; James N. Kirby Foundation; Foundation Fighting Blindness","keywords":"RPE65; Visual phototransduction; Cis-trans-Isomerases; Genetic enhancement; Retinal; Biology; Retinal pigment epithelium; Retina; Electroretinography; Retinal degeneration; Gene therapy of the human retina; Retinal Disorder; Retinitis pigmentosa; Genetics; Ophthalmology; Neuroscience; Gene; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001236473,0.0002882888,0.0003361316,0.0002298847,0.0001935375,0.0004351667,0.0001577633,0.0007460563,0.001868527],"category_scores_gemma":[0.0005638744,0.0001977295,0.000173829,0.00007289284,0.0005173353,0.0003375383,0.0002934943,0.0005406925,0.0005004308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973103,"about_ca_system_score_gemma":0.0003341728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693523,"about_ca_topic_score_gemma":0.0004891488,"domain_scores_codex":[0.9997275,0.00008681649,0.00002411182,0.00004068304,0.00008623689,0.00003457939],"domain_scores_gemma":[0.9996599,0.0000992414,0.00006656908,0.00005989558,0.00006545083,0.00004896397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112898,0.0000579148,0.0009999535,0.0001001973,0.000009440752,0.0001452066,0.00006797556,0.0001362539,0.9844616,0.0006343616,0.0002462232,0.01302801],"study_design_scores_gemma":[0.00006764859,0.001339711,0.01612402,0.00007730119,0.00005612765,0.004167741,0.0002020423,0.001208614,0.9572427,0.00104412,0.01845185,0.00001811941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.86195,0.02081057,0.09360828,0.00321734,0.0002008006,0.0006478344,0.0005109386,0.0007749142,0.01827932],"genre_scores_gemma":[0.9414259,0.006812229,0.04502913,0.0005851845,0.0000571143,0.000137968,0.0003965716,0.00005885002,0.005497064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868527,"threshold_uncertainty_score":0.006539166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04086257177631297,"score_gpt":0.3432250275997024,"score_spread":0.3023624558233894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}