{"id":"W1999224816","doi":"10.1002/ijc.23086","title":"Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function","year":2007,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cisplatin; Puma; Protein kinase B; Apoptosis; Downregulation and upregulation; Cancer research; Phosphorylation; Ovarian cancer; PI3K/AKT/mTOR pathway; Biology; Cancer cell; Kinase; Cancer; Cell biology; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003634596,0.0001127562,0.0002314464,0.0002456001,0.00002949755,0.00001724029,0.00006818086,0.0001074169,0.0002799682],"category_scores_gemma":[0.00003959099,0.0001093225,0.00007960776,0.0001815975,0.00006926936,0.0002444044,0.00002117919,0.000289005,0.000001006037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000518322,"about_ca_system_score_gemma":0.0001529312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004789444,"about_ca_topic_score_gemma":0.001423787,"domain_scores_codex":[0.9984726,0.00002356793,0.0006419662,0.0001486569,0.0005806912,0.0001324772],"domain_scores_gemma":[0.9986036,0.00003221528,0.0006098467,0.00008091054,0.0006152157,0.00005817758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003136613,0.0001663271,0.005791684,0.00007883199,0.0003041451,0.0001305323,0.001737972,0.0002863414,0.9745936,0.002829101,0.0008214541,0.01012344],"study_design_scores_gemma":[0.0102792,0.0006218858,0.1575037,0.004232644,0.0003258386,0.00009347647,0.0003440382,0.0001662737,0.8037282,0.005202478,0.01719646,0.0003057717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898887,0.003567832,0.002619608,0.001016308,0.000890038,0.0001935361,0.00001954144,0.0000090637,0.001795362],"genre_scores_gemma":[0.997717,0.000476798,0.001015602,0.0002556095,0.0004101793,0.000004109188,0.0000064231,0.00002339482,0.0000909131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1708653,"threshold_uncertainty_score":0.4458042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232221713339882,"score_gpt":0.2983649822682313,"score_spread":0.2860427651348325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}