{"id":"W1999248403","doi":"10.1128/aac.45.4.1043-1052.2001","title":"Specific Inhibition of Coxsackievirus B3 Translation and Replication by Phosphorothioate Antisense Oligodeoxynucleotides","year":2001,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Medical Research Council; Heart and Stroke Foundation of British Columbia and Yukon; Medical Research Council Canada; Heart and Stroke Foundation of Canada","keywords":"Internal ribosome entry site; Biology; Untranslated region; RNA; Viral replication; Translation (biology); Molecular biology; Five prime untranslated region; Transcription (linguistics); Messenger RNA; Eukaryotic translation; Three prime untranslated region; Infectivity; Ribosome; Sense (electronics); Virology; Virus; Chemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195488,0.0005915034,0.0002938126,0.0001555617,0.0001295767,0.0002138578,0.0002178487,0.0002309531,0.0004886865],"category_scores_gemma":[0.000132129,0.0001812471,0.000277331,0.0001285477,0.0002551046,0.0001123681,0.0001501458,0.000501822,0.0001604245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029879,"about_ca_system_score_gemma":0.000336873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007251294,"about_ca_topic_score_gemma":0.001175494,"domain_scores_codex":[0.9998168,0.00003019589,0.00002022545,0.00004813923,0.00004737442,0.00003727515],"domain_scores_gemma":[0.9998999,0.0000329005,0.00002412485,0.00001003478,0.00001584768,0.00001728577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003414237,0.000009434129,0.0000218739,0.00002295128,0.000002210596,0.000005856449,0.000004877847,0.00002838563,0.9994355,0.00003563375,0.000006956901,0.0003921048],"study_design_scores_gemma":[0.00001199944,0.0003015842,0.000568161,0.000003280525,0.000009628363,0.00005133827,0.000006237657,0.0004379999,0.9979206,0.00001595478,0.0006709362,0.000002348787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899318,0.002334149,0.005752902,0.00004292403,0.00005311122,0.00006545881,0.000197553,0.00008711132,0.001534955],"genre_scores_gemma":[0.9859996,0.002273084,0.008615744,0.000068167,0.00002198657,0.000142272,0.000583781,0.00002959897,0.002265673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007251294,"threshold_uncertainty_score":0.002167821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03172949473323351,"score_gpt":0.2948297394959765,"score_spread":0.263100244762743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}