{"id":"W1999254093","doi":"10.1038/cdd.2013.194","title":"Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment","year":2014,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Montreal Children's Hospital; Jewish General Hospital","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Neuroscience; Hippocampus; Memory impairment; Senile plaques; Caspase; Alzheimer's disease; Neuropil; Genetically modified mouse; Caspase 3; Biology; Psychology; Disease; Transgene; Apoptosis; Medicine; Cognition; Pathology; Programmed cell death; Central nervous system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152967,0.00009897032,0.0001374946,0.00005249672,0.00008571199,0.00001907176,0.00006616092,0.00005072675,0.00000902459],"category_scores_gemma":[0.00002590975,0.00005092126,0.0000594824,0.0000746449,0.0000405682,0.00004873027,0.0000356623,0.0001169183,0.000002948424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004202774,"about_ca_system_score_gemma":0.00004456419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002666328,"about_ca_topic_score_gemma":0.00006544646,"domain_scores_codex":[0.9990701,0.0002045585,0.0001132792,0.0001556133,0.0002975849,0.0001588473],"domain_scores_gemma":[0.9994901,0.00007406066,0.00007907367,0.000245759,0.00002767758,0.00008326535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001063989,0.004393493,0.9306148,0.0006164078,0.0008517395,0.0001560986,0.002897051,0.00001649407,0.00840818,0.0002961967,0.0003355838,0.05034994],"study_design_scores_gemma":[0.001745115,0.0002242785,0.9864582,0.00004511347,0.0002031308,0.00001161742,0.0001440462,0.0003058719,0.009653807,0.001153064,0.000003635685,0.0000520559],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997581,0.0005669593,0.00004755841,0.0002495133,0.00005397017,0.0005008359,0.000003043198,0.000007907961,0.0009892189],"genre_scores_gemma":[0.9996752,0.0001126051,0.000006253897,0.00006607124,0.00003902915,0.00003209029,0.00001880228,0.00000637431,0.0000436293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05584344,"threshold_uncertainty_score":0.2076509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257291241088682,"score_gpt":0.2702231515922722,"score_spread":0.244494027483404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}