{"id":"W1999257052","doi":"10.1182/blood-2007-05-088815","title":"Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Wilmot Cancer Institute, University of Rochester Medical Center; National Cancer Institute; Leukemia and Lymphoma Society","keywords":"Haematopoiesis; Leukemia; Stem cell; Progenitor cell; Myeloid leukemia; Biology; Cancer research; Myeloid; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004462085,0.000279947,0.0004782287,0.0001008897,0.0001342011,0.00002226983,0.0001021784,0.0001856048,0.00001507741],"category_scores_gemma":[0.00004456052,0.0001984735,0.00006545105,0.0002430659,0.0001403852,0.00007333056,0.00007686093,0.000322809,0.000005930267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003487815,"about_ca_system_score_gemma":0.0003682918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003917971,"about_ca_topic_score_gemma":0.00002877052,"domain_scores_codex":[0.9983823,0.00007374797,0.0003902603,0.0004040845,0.0003469966,0.0004026492],"domain_scores_gemma":[0.998708,0.0003943222,0.0001852487,0.0003563955,0.0001217078,0.0002343235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000514632,0.0009623456,0.04645772,0.000262453,0.001349445,0.000112426,0.001755201,3.66151e-7,0.9318734,0.0001619365,0.0009621014,0.01558794],"study_design_scores_gemma":[0.01194176,0.001011518,0.05950559,0.0000974461,0.0008125794,0.0003476896,0.0004377348,0.0000286172,0.9244912,0.0000380112,0.001070073,0.0002177894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914374,0.005855053,0.00001728855,0.0000906253,0.00008310155,0.001066287,0.00003257774,0.00004821737,0.001369406],"genre_scores_gemma":[0.9985115,0.0003559679,0.0005119468,0.0001151476,0.0001630033,0.00002321152,0.00001842191,0.00004123308,0.0002595961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01537015,"threshold_uncertainty_score":0.8093514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971313383709918,"score_gpt":0.2547638598019159,"score_spread":0.2350507259648167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}