{"id":"W1999257052","doi":"10.1182/blood-2007-05-088815","title":"Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Wilmot Cancer Institute, University of Rochester Medical Center; National Cancer Institute; Leukemia and Lymphoma Society","keywords":"Haematopoiesis; Leukemia; Stem cell; Progenitor cell; Myeloid leukemia; Biology; Cancer research; Myeloid; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007649165,0.0002917648,0.0002450637,0.000180079,0.00008860269,0.0001245735,0.0001155793,0.0001339244,0.0006520933],"category_scores_gemma":[0.00006502141,0.00006915744,0.0001174656,0.0001085072,0.000121482,0.00012168,0.0001410217,0.0002680279,0.0001773805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001446951,"about_ca_system_score_gemma":0.0001612689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002180881,"about_ca_topic_score_gemma":0.0004411844,"domain_scores_codex":[0.9999489,0.000007252147,0.000005493527,0.00001117808,0.0000155932,0.00001161778],"domain_scores_gemma":[0.9999611,0.000008862336,0.00001186785,0.000005828236,0.000005253215,0.00000704576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010217,0.00001222045,0.000225275,0.00002750299,0.000001989684,0.00004799173,0.00001493759,0.00004474849,0.9981184,0.00003246859,0.00001332086,0.001360043],"study_design_scores_gemma":[0.00001195838,0.0004808435,0.003197372,0.00000233707,0.000006524937,0.0002240502,0.0000127591,0.0002852903,0.9950981,0.00001918609,0.0006599242,0.000001725722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963496,0.001065655,0.001698776,0.0000201835,0.000007931511,0.00003098269,0.000303767,0.00006419053,0.000458926],"genre_scores_gemma":[0.9959459,0.0007716036,0.002043369,0.00001988945,0.00000408682,0.0000472609,0.0004715405,0.0000066802,0.0006898037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006520933,"threshold_uncertainty_score":0.00218153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971313383709918,"score_gpt":0.2547638598019159,"score_spread":0.2350507259648167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}