{"id":"W1999277077","doi":"10.1021/nn900488u","title":"Nanoscale Aggregation of Cellular β<sub>2</sub>-Adrenergic Receptors Measured by Plasmonic Interactions of Functionalized Nanoparticles","year":2009,"lang":"en","type":"article","venue":"ACS Nano","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Microstructural Sciences; Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Cardiac myocyte; Biophysics; Receptor; Materials science; Nanoparticle; Silver nanoparticle; Cell membrane; Raman scattering; Cell surface receptor; Adrenergic receptor; Membrane; Nanotechnology; Myocyte; Chemistry; Raman spectroscopy; Cell biology; Biochemistry; Biology; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725226,0.0001441688,0.0002004971,0.00005932095,0.00006790804,0.000009710835,0.0001279252,0.0001302373,0.00008532099],"category_scores_gemma":[0.00006614804,0.0001408337,0.0001314513,0.0001642589,0.00004695367,0.00001166676,0.00002452875,0.0000586779,0.000005594089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001870148,"about_ca_system_score_gemma":0.0000543873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000107935,"about_ca_topic_score_gemma":0.000007682788,"domain_scores_codex":[0.9989116,0.00007591508,0.0003717658,0.0002529586,0.0002120769,0.0001756552],"domain_scores_gemma":[0.9992813,0.00001673918,0.0002343334,0.0002357772,0.0001723058,0.00005953384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001632719,0.0001317276,0.00006861426,0.00000777489,0.00004798413,2.482156e-7,0.00003378308,0.0001615941,0.9916713,0.0001214122,0.001285773,0.006306564],"study_design_scores_gemma":[0.0005445745,0.0004397125,0.00004907053,0.00003536689,0.00003403217,0.000002989052,0.00004568825,0.0000414794,0.9942173,0.0002461623,0.004204591,0.0001390033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996573,0.001247893,0.001507569,0.0000548261,0.0003361389,0.0001199928,0.00001787634,0.00001283525,0.0001299028],"genre_scores_gemma":[0.998899,0.0002403193,0.0003132134,0.00004832952,0.00005880986,0.00001041921,0.0001683481,0.00001546062,0.0002460731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006167561,"threshold_uncertainty_score":0.5743032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008768175856142785,"score_gpt":0.2142303586381847,"score_spread":0.205462182782042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}