{"id":"W1999277077","doi":"10.1021/nn900488u","title":"Nanoscale Aggregation of Cellular β<sub>2</sub>-Adrenergic Receptors Measured by Plasmonic Interactions of Functionalized Nanoparticles","year":2009,"lang":"en","type":"article","venue":"ACS Nano","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Microstructural Sciences; Steacie Institute for Molecular Sciences","funders":"Canadian Institutes of Health Research","keywords":"Cardiac myocyte; Biophysics; Receptor; Materials science; Nanoparticle; Silver nanoparticle; Cell membrane; Raman scattering; Cell surface receptor; Adrenergic receptor; Membrane; Nanotechnology; Myocyte; Chemistry; Raman spectroscopy; Cell biology; Biochemistry; Biology; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451648,0.0002480307,0.0001718935,0.000147664,0.0001665511,0.0002741495,0.0001549994,0.0003241171,0.0007070694],"category_scores_gemma":[0.000211052,0.0001626928,0.0001462997,0.00007044822,0.0002061288,0.000239598,0.0002054893,0.0003730543,0.000281754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00028396,"about_ca_system_score_gemma":0.00006054987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003301675,"about_ca_topic_score_gemma":0.0003808024,"domain_scores_codex":[0.999858,0.00002030083,0.000007414551,0.00003927542,0.00005242456,0.00002255432],"domain_scores_gemma":[0.9998921,0.00003310015,0.00002601947,0.000009104731,0.00002826162,0.00001146169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001259813,0.000004149339,0.00008466133,0.000007836612,0.000002894874,0.00001063941,0.00001145071,0.00005980718,0.9993588,0.00003881193,0.00002187638,0.0003865058],"study_design_scores_gemma":[0.000003946955,0.00006837523,0.002742391,0.000002145337,0.000009790185,0.00006934866,0.0000244256,0.002310473,0.9942753,0.00005742302,0.000432569,0.000003844652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986824,0.000629825,0.009822504,0.00008915338,0.00002213758,0.00001591843,0.00007632365,0.0001050455,0.002415175],"genre_scores_gemma":[0.9917571,0.0002910011,0.005985354,0.0001180908,0.00001466621,0.00003374807,0.0001390359,0.00002370082,0.001637353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007070694,"threshold_uncertainty_score":0.002365351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008768175856142785,"score_gpt":0.2142303586381847,"score_spread":0.205462182782042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}