{"id":"W1999286385","doi":"10.1016/j.bmcl.2009.03.113","title":"SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Moiety; Enzyme; Methyltransferase; DNMT1; Stereochemistry; Enzyme inhibitor; Biochemistry; DNA methyltransferase; Alkylation; Methylation; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002132874,0.0003390652,0.0003479182,0.0001745075,0.0002123171,0.0002791084,0.0003304141,0.0005083711,0.003341269],"category_scores_gemma":[0.0002209587,0.0001452842,0.0002677249,0.0001244249,0.0002052338,0.0002444847,0.0001711425,0.0007409355,0.0009971173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001862094,"about_ca_system_score_gemma":0.00029377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005908703,"about_ca_topic_score_gemma":0.0006804937,"domain_scores_codex":[0.9999095,0.0000238472,0.000007496803,0.00001237297,0.00001937603,0.00002730651],"domain_scores_gemma":[0.9999129,0.00002658399,0.0000184408,0.00001054417,0.00001502514,0.00001651185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002493324,0.0001660309,0.0004101754,0.0002550926,0.00004585347,0.0007506852,0.00004969734,0.001291939,0.9744272,0.0008589444,0.001107444,0.01814361],"study_design_scores_gemma":[0.0002907978,0.003168551,0.001348161,0.00002065313,0.0001125397,0.001044746,0.00004995788,0.002273451,0.9786431,0.0002702888,0.01276202,0.00001556136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9295542,0.02433298,0.01005737,0.001934814,0.000683641,0.0001074117,0.0008415724,0.0003865201,0.03210141],"genre_scores_gemma":[0.9850647,0.005458913,0.001907944,0.0003795273,0.0001270241,0.00002907344,0.0005037797,0.00001604614,0.006513013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003341269,"threshold_uncertainty_score":0.0111776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119160742697589,"score_gpt":0.2606035091084085,"score_spread":0.2494119016814326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}