{"id":"W1999286385","doi":"10.1016/j.bmcl.2009.03.113","title":"SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Chemistry; Moiety; Enzyme; Methyltransferase; DNMT1; Stereochemistry; Enzyme inhibitor; Biochemistry; DNA methyltransferase; Alkylation; Methylation; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003556329,0.000336347,0.0003618262,0.00004993227,0.0001104309,0.00002456417,0.000376843,0.0002761994,0.00009116416],"category_scores_gemma":[0.00009137738,0.000328923,0.0001405475,0.0001744561,0.0001926181,0.0000114724,0.00003557177,0.0002025112,0.000003869557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004354328,"about_ca_system_score_gemma":0.00009061271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002656992,"about_ca_topic_score_gemma":0.000005043502,"domain_scores_codex":[0.9979832,0.00007416777,0.0005426068,0.0005813624,0.000401125,0.0004174937],"domain_scores_gemma":[0.9987894,0.00001734093,0.0001846194,0.0006291664,0.0001062648,0.0002732413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006713494,0.0001404056,0.0005693099,0.00005969097,0.00005407236,0.00001667888,0.0001002897,0.000005542313,0.9976483,0.00001684232,0.0003928629,0.0009288662],"study_design_scores_gemma":[0.001013296,0.0004920412,0.001681591,0.00004900433,0.00009369661,0.00001492113,0.000155473,0.000007559818,0.9944019,0.00006288836,0.001682618,0.000344973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947646,0.002591647,0.0008654227,0.00105091,0.0001201326,0.0001642578,0.00002328538,0.0000307611,0.0003890133],"genre_scores_gemma":[0.9970255,0.0001246047,0.0003272796,0.0006538517,0.001362071,0.000003357447,0.0003609129,0.00003809227,0.0001043359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003246366,"threshold_uncertainty_score":0.9999163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119160742697589,"score_gpt":0.2606035091084085,"score_spread":0.2494119016814326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}