{"id":"W1999287382","doi":"10.1038/nature09755","title":"The RAG2 C terminus suppresses genomic instability and lymphomagenesis","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Eye Institute","keywords":"RAG2; Recombination-activating gene; V(D)J recombination; Recombinase; Biology; Genome instability; T-cell receptor; Ataxia-telangiectasia; Homologous recombination; Genetics; Gene rearrangement; Recombination signal sequences; DNA damage; Molecular biology; Non-homologous end joining; DNA; Gene; T cell; Recombination; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382889,0.000536993,0.0003159308,0.0006399342,0.0002928095,0.0007464962,0.0005673689,0.0006550957,0.003351568],"category_scores_gemma":[0.0002262585,0.0003329584,0.0003141614,0.000290455,0.0005926639,0.0002964282,0.0003889993,0.001222193,0.0009933326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004595146,"about_ca_system_score_gemma":0.0002965423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005123775,"about_ca_topic_score_gemma":0.000692038,"domain_scores_codex":[0.9996961,0.00005445489,0.0000397071,0.00005680608,0.00007887954,0.00007401896],"domain_scores_gemma":[0.9994063,0.0001245596,0.000147263,0.0001066674,0.00002461143,0.0001905656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643512,0.00003468672,0.00006077812,0.00001335833,0.000005540926,0.00006280324,0.000005093512,0.00009924051,0.9988115,0.0001859161,0.00005546862,0.0005012573],"study_design_scores_gemma":[0.00003492424,0.0001360088,0.0008624734,0.00000289213,0.0000136092,0.0003544736,0.00001683629,0.0008448937,0.9952372,0.00007170461,0.002419792,0.000005177114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909291,0.001505306,0.002741435,0.0003018799,0.00009595055,0.00002181697,0.000566013,0.0004484228,0.003390119],"genre_scores_gemma":[0.9940402,0.0003147523,0.0009385026,0.00006839238,0.00002598743,0.00001576813,0.0004130641,0.000103407,0.004079911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003351568,"threshold_uncertainty_score":0.01121211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006952976125080284,"score_gpt":0.2163294700863967,"score_spread":0.2093764939613165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}