{"id":"W1999287382","doi":"10.1038/nature09755","title":"The RAG2 C terminus suppresses genomic instability and lymphomagenesis","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Eye Institute","keywords":"RAG2; Recombination-activating gene; V(D)J recombination; Recombinase; Biology; Genome instability; T-cell receptor; Ataxia-telangiectasia; Homologous recombination; Genetics; Gene rearrangement; Recombination signal sequences; DNA damage; Molecular biology; Non-homologous end joining; DNA; Gene; T cell; Recombination; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376864,0.00009872871,0.00006663147,0.000009551815,0.0001079,0.000018709,0.0001963403,0.0005393765,0.00001922747],"category_scores_gemma":[0.00008683922,0.00006794481,0.00004286291,0.00002916706,0.00008089431,0.000002381612,0.0001564213,0.0001851606,0.00000470291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008100852,"about_ca_system_score_gemma":0.00003731687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001053233,"about_ca_topic_score_gemma":0.00004077143,"domain_scores_codex":[0.9994146,0.00004196003,0.0000837723,0.0002442961,0.00006396922,0.000151437],"domain_scores_gemma":[0.9994775,0.00001230392,0.00003252915,0.0003917305,0.00003963951,0.00004626683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001291417,0.00003970196,0.00385068,0.00001637636,0.00004301883,0.00001043672,0.0001187981,1.776602e-7,0.9763683,0.0003593643,0.00257284,0.01649116],"study_design_scores_gemma":[0.0002522775,0.00008649122,0.04529645,0.00000248857,0.0000149573,0.000046773,0.00006795536,0.000006450983,0.8861793,0.0005189412,0.06739972,0.0001281772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920797,0.004810845,0.00001892582,0.00006075284,0.0002123491,0.0001180395,0.00001367453,0.00001578928,0.002669937],"genre_scores_gemma":[0.9980503,0.0002321138,0.0006634551,0.0002734547,0.00007886677,0.00001355604,0.00001003921,0.0000137881,0.0006644665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09018898,"threshold_uncertainty_score":0.4160166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006952976125080284,"score_gpt":0.2163294700863967,"score_spread":0.2093764939613165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}