{"id":"W1999288550","doi":"10.1002/ana.22403","title":"Genome‐wide association studies of cerebral white matter lesion burden","year":2011,"lang":"en","type":"review","venue":"Annals of Neurology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health; U.S. Public Health Service; Hjartavernd","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Hyperintensity; Locus (genetics); Genetic association; Dementia; White matter; SNP; Medicine; Genetic architecture; Allele; Genetics; Quantitative trait locus; Biology; Internal medicine; Magnetic resonance imaging; Disease; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00299773,0.0008168202,0.0009242403,0.001493035,0.0003678044,0.0008834039,0.0006389238,0.0007042428,0.002550498],"category_scores_gemma":[0.006524913,0.0003532395,0.001579364,0.002859079,0.0004284171,0.0002812135,0.0006777579,0.0005790684,0.0002069094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542761,"about_ca_system_score_gemma":0.0004037295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00361417,"about_ca_topic_score_gemma":0.004697153,"domain_scores_codex":[0.9983596,0.0005338768,0.0001600369,0.000663034,0.0001827006,0.0001007514],"domain_scores_gemma":[0.9955056,0.002226936,0.00143783,0.0003891722,0.0002505441,0.0001898855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001729246,0.00007585383,0.951386,0.0004860146,0.02674921,0.0006238879,0.0001114173,0.001013934,0.003976074,0.0001457803,0.0008177867,0.01288484],"study_design_scores_gemma":[0.000238112,0.0002435916,0.9843672,0.0001176176,0.01137098,0.0007819679,0.00007496929,0.0007066581,0.0006350356,0.0003839193,0.001065816,0.00001412314],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9747206,0.02128558,0.001232442,0.0005215424,0.00007535749,0.00002313345,0.00138019,0.00006604402,0.0006950899],"genre_scores_gemma":[0.9933066,0.004349281,0.0009571926,0.0001278321,0.0000877402,0.00002575481,0.000929114,0.00001346991,0.0002030366],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00361417,"threshold_uncertainty_score":0.0158537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1330308446109028,"score_gpt":0.376142244235348,"score_spread":0.2431113996244453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}