{"id":"W1999325713","doi":"10.3389/fonc.2014.00077","title":"Oncolytic Virus-Mediated Reversal of Impaired Tumor Antigen Presentation","year":2014,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; Beatrice Hunter Cancer Research Institute; Nova Scotia Health Research Foundation; Cancer Research Institute","keywords":"Oncolytic virus; Antigen presentation; Antigen; Immune system; Tumor microenvironment; Immunology; Antigen processing; Antigen-presenting cell; Cancer; Medicine; Tumor antigen; T cell; Acquired immune system; Major histocompatibility complex; Cancer research; Immunotherapy; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640833,0.000668689,0.0007124973,0.00135343,0.000170136,0.0006104707,0.0005934029,0.0007602764,0.00155296],"category_scores_gemma":[0.0003060954,0.0002098039,0.000244074,0.001087164,0.0004731078,0.0008747001,0.0004517087,0.001174541,0.001202991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006824993,"about_ca_system_score_gemma":0.0005814734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005581168,"about_ca_topic_score_gemma":0.0009626793,"domain_scores_codex":[0.9999171,0.00001215763,0.000009185397,0.00001721283,0.00003202147,0.00001226837],"domain_scores_gemma":[0.999894,0.00003884817,0.00001964856,0.000005052042,0.0000296737,0.00001273267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007141251,0.00008012816,0.0001646183,0.007542769,0.0000524662,0.0001842265,0.00004383565,0.0004627377,0.01232706,0.008292386,0.0169088,0.9538698],"study_design_scores_gemma":[0.00001046322,0.00009766825,0.000542626,0.0008119565,0.00003850086,0.00100685,0.0000323829,0.0001133976,0.004859994,0.001608428,0.9908633,0.00001444047],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004559471,0.9964783,0.000523386,0.0002008327,0.0002020659,0.000006967078,0.0000225928,0.00001804878,0.002091829],"genre_scores_gemma":[0.002546202,0.9954376,0.0003931497,0.0001388025,0.00006951579,0.000009746132,0.00003977042,0.000002953853,0.001362224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00155296,"threshold_uncertainty_score":0.0051952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02824824359184799,"score_gpt":0.3692200922255912,"score_spread":0.3409718486337432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}