{"id":"W1999333320","doi":"10.2353/ajpath.2008.070952","title":"Pharmacological Blockade of A2A Receptors Prevents Dermal Fibrosis in a Model of Elevated Tissue Adenosine","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases; School of Medicine, New York University; National Institute of General Medical Sciences; National Institute on Alcohol Abuse and Alcoholism; National Research Foundation; National Institutes of Health; King Pharmaceuticals; National Heart, Lung, and Blood Institute; Scleroderma Foundation; Ministerio de Educación, Cultura y Deporte; York University; Arthritis National Research Foundation","keywords":"Adenosine; Fibrosis; Adenosine receptor; Adenosine A3 receptor; Bleomycin; Endocrinology; Internal medicine; Purinergic signalling; Pulmonary fibrosis; Adenosine A1 receptor; Inflammation; Adenosine A2A receptor; Receptor; Adenosine deaminase; Chemistry; Pharmacology; Biology; Medicine; Agonist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002901741,0.0005317879,0.0004778484,0.0003661662,0.0004373532,0.0003997689,0.0004156499,0.0005135562,0.002502066],"category_scores_gemma":[0.0002357403,0.0003467393,0.0003317239,0.0001900136,0.0006036257,0.0004923738,0.0001804391,0.001865829,0.0005198824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002323133,"about_ca_system_score_gemma":0.0003708935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006130446,"about_ca_topic_score_gemma":0.001248996,"domain_scores_codex":[0.9997516,0.00006087242,0.0000193787,0.00003889839,0.00005125927,0.00007792958],"domain_scores_gemma":[0.999658,0.00009574089,0.00006000673,0.00004774814,0.00001605475,0.0001223314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001936973,0.0004174471,0.00006548056,0.00004313525,0.00001045566,0.0001228261,0.00002395011,0.00009738827,0.9958775,0.0001710489,0.00008431781,0.001149331],"study_design_scores_gemma":[0.000345906,0.003931458,0.001933703,0.00001216887,0.0000363892,0.000411742,0.00009473756,0.001669081,0.9907066,0.0001458447,0.0007017651,0.00001062651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949675,0.0007635714,0.001856763,0.0002438427,0.0001274331,0.00005761593,0.0001146003,0.00009695766,0.001771697],"genre_scores_gemma":[0.9955229,0.0004779746,0.001519875,0.00008084369,0.00004767041,0.00006200079,0.00009893272,0.00001986243,0.002169862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002502066,"threshold_uncertainty_score":0.008370221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02858630413003533,"score_gpt":0.298806946173492,"score_spread":0.2702206420434566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}