{"id":"W1999333889","doi":"10.1038/ncomms4550","title":"Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Western University; University of Ottawa","funders":"Krembil Foundation; Fondation Brain Canada; Heart and Stroke Foundation of Canada","keywords":"Bioenergetics; Oxidative phosphorylation; Mitochondrion; Cell biology; Biology; Acidosis; Mitochondrial DNA; Extracellular; Reactive oxygen species; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279094,0.0002537049,0.0004506999,0.0001274157,0.0001957006,0.0005892276,0.000308336,0.0004184357,0.001610206],"category_scores_gemma":[0.0002652374,0.0001049279,0.0002180659,0.0001344783,0.0002443917,0.0004976374,0.0006008172,0.0007553077,0.0004747902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886617,"about_ca_system_score_gemma":0.0003764021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004800761,"about_ca_topic_score_gemma":0.0008661143,"domain_scores_codex":[0.9997714,0.00003665805,0.00002661797,0.00003569502,0.00007331208,0.00005636498],"domain_scores_gemma":[0.9997991,0.00002961802,0.00005666502,0.00002874899,0.00003332848,0.00005262976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005864628,0.00003117247,0.0003579353,0.0001098162,0.000009178946,0.0001285805,0.00002435357,0.0001906946,0.9946864,0.0005252552,0.0001764687,0.003173727],"study_design_scores_gemma":[0.0000616713,0.0008317591,0.009811711,0.00003100212,0.00003211785,0.0007060764,0.0001138658,0.001683118,0.9746552,0.0007214939,0.01133689,0.0000150583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970509,0.01073948,0.009381473,0.001554568,0.0004030835,0.0000613134,0.0006433275,0.0002171395,0.006490664],"genre_scores_gemma":[0.9936882,0.002207439,0.001550136,0.000284513,0.00006197282,0.00002741713,0.0002884728,0.00002077039,0.001871141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001610206,"threshold_uncertainty_score":0.00538671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144165142546162,"score_gpt":0.2580013549659027,"score_spread":0.246559703540441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}