{"id":"W1999333889","doi":"10.1038/ncomms4550","title":"Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Western University; University of Ottawa","funders":"Krembil Foundation; Fondation Brain Canada; Heart and Stroke Foundation of Canada","keywords":"Bioenergetics; Oxidative phosphorylation; Mitochondrion; Cell biology; Biology; Acidosis; Mitochondrial DNA; Extracellular; Reactive oxygen species; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957681,0.0001209516,0.0001097321,0.00006893522,0.0002193716,0.0000328615,0.0003355125,0.0003599242,0.00002081742],"category_scores_gemma":[0.0004065965,0.000123555,0.00005007628,0.0001345595,0.00005567002,0.000006151046,0.0002921333,0.0002801022,0.00003151759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001305137,"about_ca_system_score_gemma":0.00002548588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001429016,"about_ca_topic_score_gemma":0.0004778056,"domain_scores_codex":[0.9990819,0.0002418841,0.0001637157,0.0002775537,0.00009148045,0.0001434672],"domain_scores_gemma":[0.9985995,0.00007263218,0.00006316721,0.001055565,0.000113634,0.00009553977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001703137,0.00006517821,0.004061692,0.000005928809,0.00002145806,7.078482e-8,0.00004239557,0.00003401511,0.9696595,0.01271598,0.0110736,0.002149871],"study_design_scores_gemma":[0.0008868189,0.0003574126,0.02974583,0.000007261536,0.00004429779,0.000006095429,0.00008295613,0.0001640809,0.03083747,0.001067971,0.9365231,0.0002766523],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.703982,0.003473324,0.2542141,0.0114076,0.005175098,0.001348792,0.00009738965,0.0001601211,0.02014155],"genre_scores_gemma":[0.9825457,0.0002141511,0.013765,0.001977239,0.000517434,0.00005432983,0.0004170355,0.00001880682,0.0004902978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.938822,"threshold_uncertainty_score":0.5038426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144165142546162,"score_gpt":0.2580013549659027,"score_spread":0.246559703540441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}