{"id":"W1999340340","doi":"10.1210/me.2005-0438","title":"Gene Profiling on Mixed Embryonic Stem Cell Populations Reveals a Biphasic Role for β-Catenin in Osteogenic Differentiation","year":2006,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fraunhofer-Institut für Zelltherapie und Immunologie; Alberta Heritage Foundation for Medical Research; Stem Cell Network","keywords":"Biology; Wnt signaling pathway; Bone morphogenetic protein 2; Embryonic stem cell; Bone morphogenetic protein; Cell biology; Retinoic acid; Gene expression; Population; Progenitor cell; Stem cell; Cellular differentiation; Gene expression profiling; Molecular biology; Cell culture; Signal transduction; Gene; In vitro; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00013111,0.000258276,0.0002685718,0.0002785785,0.00009699506,0.0000263351,0.0002900359,0.0002052286,0.000006246922],"category_scores_gemma":[0.00002370905,0.0002764005,0.0001793336,0.0001933777,0.00004833744,0.000005181881,0.0001381454,0.0001656702,0.00002796352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007746803,"about_ca_system_score_gemma":0.00006810433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000462545,"about_ca_topic_score_gemma":0.0001086129,"domain_scores_codex":[0.9977427,0.0002234787,0.0003938988,0.0006865082,0.0001902184,0.0007631612],"domain_scores_gemma":[0.9992213,0.00002537287,0.000132287,0.000469228,0.00008592286,0.00006593513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001304302,0.0001374664,0.005942671,0.00003715961,0.00002444298,0.00002771021,0.00000571889,0.001572321,0.9899423,0.0009393821,0.0001002362,0.001140225],"study_design_scores_gemma":[0.001715212,0.0003650388,0.009872252,0.000009531579,0.00002484998,0.00002616251,0.00002273004,0.0006162735,0.9858103,0.0007137562,0.0005635372,0.0002603013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925007,0.001513682,0.004065294,0.0001776838,0.0001664875,0.001039042,0.00005145729,0.00002909591,0.0004565679],"genre_scores_gemma":[0.9957212,0.0000415725,0.001341983,0.00007379569,0.00009310054,0.0004262842,0.001018548,0.00005965466,0.001223881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004131882,"threshold_uncertainty_score":0.9999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786038013656798,"score_gpt":0.2655377527942354,"score_spread":0.2476773726576674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}