{"id":"W1999340340","doi":"10.1210/me.2005-0438","title":"Gene Profiling on Mixed Embryonic Stem Cell Populations Reveals a Biphasic Role for β-Catenin in Osteogenic Differentiation","year":2006,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Fraunhofer-Institut für Zelltherapie und Immunologie; Alberta Heritage Foundation for Medical Research; Stem Cell Network","keywords":"Biology; Wnt signaling pathway; Bone morphogenetic protein 2; Embryonic stem cell; Bone morphogenetic protein; Cell biology; Retinoic acid; Gene expression; Population; Progenitor cell; Stem cell; Cellular differentiation; Gene expression profiling; Molecular biology; Cell culture; Signal transduction; Gene; In vitro; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189404,0.0001643922,0.000293212,0.0004405519,0.0001247274,0.0004122957,0.00009374054,0.000157835,0.0005442789],"category_scores_gemma":[0.000138022,0.0001202307,0.0002034619,0.0003343382,0.000147437,0.0001413166,0.0001809497,0.000254256,0.000210311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207056,"about_ca_system_score_gemma":0.0001578359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003508096,"about_ca_topic_score_gemma":0.001058245,"domain_scores_codex":[0.9997532,0.00001916776,0.00002607822,0.00005959411,0.0001197213,0.00002212791],"domain_scores_gemma":[0.9999075,0.00002569949,0.0000151569,0.000008480128,0.00002522223,0.00001790616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003613218,0.000003434819,0.0006893767,0.000009708353,0.000002939436,0.00001083918,0.0000103086,0.00001483616,0.9983101,0.00001005934,0.000003330541,0.000898922],"study_design_scores_gemma":[0.000005431807,0.0002487214,0.05309281,0.000007235634,0.00004345916,0.0002376011,0.000103723,0.0007378503,0.9441319,0.00005340962,0.00133123,0.000006644263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990035,0.001766726,0.00654029,0.00003102243,0.000008693005,0.000037661,0.0007096111,0.00003941551,0.0008316282],"genre_scores_gemma":[0.983023,0.001635685,0.009958633,0.0001021147,0.00001163152,0.0001175049,0.002056023,0.00002645073,0.003068963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005442789,"threshold_uncertainty_score":0.001820803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01786038013656798,"score_gpt":0.2655377527942354,"score_spread":0.2476773726576674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}