{"id":"W1999341950","doi":"10.1111/j.1365-2567.2006.02452.x","title":"CD4<sup>+</sup> Th1 cells promote CD8<sup>+</sup> Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes","year":2006,"lang":"en","type":"article","venue":"Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Cytotoxic T cell; CD8; Adoptive cell transfer; T cell; Immunotherapy; Biology; Immunology; Cell biology; T-cell receptor; Antigen-presenting cell; Cancer research; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088102,0.0004923168,0.0002145133,0.0001716902,0.0001013927,0.0002571596,0.0001154456,0.0002000842,0.001171637],"category_scores_gemma":[0.00008091408,0.0001062732,0.000149499,0.00005940774,0.0001621948,0.0001347031,0.0001310437,0.0005555586,0.0003613633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171603,"about_ca_system_score_gemma":0.0001826567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002747723,"about_ca_topic_score_gemma":0.0004115606,"domain_scores_codex":[0.9998829,0.00002175419,0.000009535231,0.00001681205,0.00002438408,0.0000444846],"domain_scores_gemma":[0.9999285,0.00001149277,0.00002111407,0.00000685624,0.00001054818,0.00002159383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536089,0.00006036721,0.0002808333,0.00004014655,0.0000027025,0.00003472907,0.00001555602,0.0001139374,0.997604,0.00004252008,0.00004889301,0.0016027],"study_design_scores_gemma":[0.000045686,0.0007770213,0.002942839,0.000008001562,0.00002106423,0.0002248041,0.00002394434,0.001405107,0.9921249,0.00003938436,0.0023845,0.000002856179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959188,0.001030608,0.001597587,0.00007851902,0.00001648823,0.0000291152,0.00008256132,0.0000791726,0.001167158],"genre_scores_gemma":[0.9948908,0.0005582015,0.001681181,0.00004534121,0.00002970726,0.00004713831,0.00020053,0.00001537299,0.002531709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171637,"threshold_uncertainty_score":0.003919542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007432998238424292,"score_gpt":0.2103468847966881,"score_spread":0.2029138865582638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}