{"id":"W1999341950","doi":"10.1111/j.1365-2567.2006.02452.x","title":"CD4<sup>+</sup> Th1 cells promote CD8<sup>+</sup> Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes","year":2006,"lang":"en","type":"article","venue":"Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Cytotoxic T cell; CD8; Adoptive cell transfer; T cell; Immunotherapy; Biology; Immunology; Cell biology; T-cell receptor; Antigen-presenting cell; Cancer research; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001126318,0.0008526362,0.001395713,0.0006228939,0.0005567645,0.00005840134,0.0008288522,0.0008765693,0.001293396],"category_scores_gemma":[0.00009266321,0.0008025033,0.0003227803,0.0005408716,0.001940645,0.000363532,0.0002895206,0.0005799989,0.0002630161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372646,"about_ca_system_score_gemma":0.000256615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001875201,"about_ca_topic_score_gemma":0.00001723702,"domain_scores_codex":[0.9927824,0.003461627,0.001499798,0.0009483441,0.0001478796,0.001159936],"domain_scores_gemma":[0.9967319,0.001081267,0.0007125356,0.001076911,0.0003557349,0.00004162678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01874316,0.0008838446,0.000401151,0.00005768251,0.0006522698,0.00002190663,0.002167844,0.0004318663,0.9651772,0.00004111227,0.006184043,0.005237924],"study_design_scores_gemma":[0.00720847,0.002100297,0.001862012,0.00008695317,0.00007554502,0.0001676191,0.001233649,0.0004200644,0.8987231,0.000133044,0.08723484,0.000754452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9170043,0.07950797,0.001045192,0.0002125757,0.0005747515,0.0009767039,0.0002532298,0.0002356889,0.000189552],"genre_scores_gemma":[0.9905131,0.002895015,0.0001724838,0.000396269,0.00005236349,0.00008837321,0.0007550372,0.0001423229,0.004985059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0810508,"threshold_uncertainty_score":0.9996195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007432998238424292,"score_gpt":0.2103468847966881,"score_spread":0.2029138865582638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}