{"id":"W1999362670","doi":"10.1002/1439-7633(20021004)3:10<1023::aid-cbic1023>3.0.co;2-9","title":"The First Orally Active Low Molecular Weight Agonists for the LH Receptor: Thienopyr(im)idines with Therapeutic Potential for Ovulation Induction","year":2002,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Ovulation; Luteinizing hormone; Pharmacology; Endogeny; Receptor; In vivo; Chemistry; Ovulation induction; Agonist; Hormone; Oral administration; Mode of action; Orally active; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002743753,0.0002634073,0.0002718089,0.00004915294,0.0006130895,0.00007102788,0.0001954985,0.0001402238,0.0000309018],"category_scores_gemma":[0.0001994298,0.0001448642,0.0001949927,0.0001883514,0.0002533865,0.0001230522,0.00002787025,0.0001897615,0.00001443538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000130905,"about_ca_system_score_gemma":0.00005173791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006181274,"about_ca_topic_score_gemma":0.000007204646,"domain_scores_codex":[0.998587,0.0000221789,0.0002398362,0.0004865295,0.0003066666,0.0003577725],"domain_scores_gemma":[0.9984232,0.0002193774,0.0001987942,0.0006075305,0.0004912683,0.00005988964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003615736,0.0003740403,0.0001949398,0.0001660171,0.001302336,0.000004242953,0.001154903,0.0001022381,0.8879491,0.00104635,0.005871377,0.09821872],"study_design_scores_gemma":[0.003246809,0.0005512993,0.002808313,0.00004984714,0.0004756227,0.00005538128,0.0003232339,0.002797411,0.9365559,0.000409014,0.05247946,0.0002477287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9154129,0.006304972,0.01602251,0.05645355,0.0007070843,0.004509357,0.00002069364,0.0001417105,0.0004272414],"genre_scores_gemma":[0.9956235,0.0001967155,0.0008091141,0.0003114213,0.0009490604,0.0006131331,0.00004244318,0.00006512109,0.00138953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09797098,"threshold_uncertainty_score":0.590739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362495046455223,"score_gpt":0.2324855058501459,"score_spread":0.2188605553855937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}