{"id":"W1999362670","doi":"10.1002/1439-7633(20021004)3:10<1023::aid-cbic1023>3.0.co;2-9","title":"The First Orally Active Low Molecular Weight Agonists for the LH Receptor: Thienopyr(im)idines with Therapeutic Potential for Ovulation Induction","year":2002,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Ovulation; Luteinizing hormone; Pharmacology; Endogeny; Receptor; In vivo; Chemistry; Ovulation induction; Agonist; Hormone; Oral administration; Mode of action; Orally active; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008048881,0.0002316413,0.0001825098,0.00009386442,0.00006688909,0.0001770224,0.0001512943,0.0002397902,0.001786146],"category_scores_gemma":[0.00008389333,0.0001150025,0.00007282267,0.00008060164,0.0001674377,0.0002327225,0.0001155665,0.0004210929,0.0006574224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483003,"about_ca_system_score_gemma":0.00007243605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001052935,"about_ca_topic_score_gemma":0.0002803566,"domain_scores_codex":[0.9999788,0.00000416531,0.000001806388,0.000003527946,0.000003826326,0.000007906752],"domain_scores_gemma":[0.9999788,0.000002576458,0.000008441637,0.000002298956,0.000002148562,0.000005690872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008874097,0.00009464399,0.0003891536,0.0005236454,0.00001239009,0.0004581293,0.0001169783,0.0003438417,0.9015229,0.004104392,0.002075301,0.08947121],"study_design_scores_gemma":[0.000302259,0.004750419,0.003174125,0.00007246935,0.0000476805,0.00187973,0.00008919358,0.000793776,0.8672562,0.001255615,0.1203408,0.00003776712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.843058,0.1002806,0.02135124,0.002429816,0.0006132558,0.0003457214,0.001106363,0.000449069,0.03036595],"genre_scores_gemma":[0.9417568,0.03528314,0.009621683,0.0006117712,0.0001635878,0.000123463,0.0003727644,0.00003431138,0.01203244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786146,"threshold_uncertainty_score":0.005975246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362495046455223,"score_gpt":0.2324855058501459,"score_spread":0.2188605553855937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}