{"id":"W1999388852","doi":"10.1161/circresaha.115.301130","title":"The Metabolic Theory of Pulmonary Arterial Hypertension","year":2014,"lang":"en","type":"review","venue":"Circulation Research","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Mitochondrion; Pulmonary hypertension; Biology; Cancer research; Bioinformatics; Medicine; Pathology; Internal medicine; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003749937,0.0003200071,0.001687234,0.0006342123,0.0005114785,0.00005976648,0.0003825821,0.0003702841,0.0002079735],"category_scores_gemma":[0.001480969,0.0001739498,0.0006642452,0.000950804,0.0005519047,0.00006721485,0.0002222508,0.0009132219,0.0005542163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009456897,"about_ca_system_score_gemma":0.000763478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002541263,"about_ca_topic_score_gemma":0.000001055812,"domain_scores_codex":[0.9939533,0.002289034,0.0007861183,0.0005488712,0.001736122,0.000686536],"domain_scores_gemma":[0.9946539,0.002565317,0.000218056,0.001270192,0.0009611725,0.0003313679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001726275,0.0002864237,0.00005910849,0.002951896,0.0003993622,0.0003743097,0.000004663987,4.021985e-7,0.00004870863,0.00101629,0.0008398207,0.9938464],"study_design_scores_gemma":[0.000480489,0.0001004146,0.003298025,0.003566175,0.0005352696,0.000814412,0.00002351613,0.0002753,0.000003669788,0.0009866939,0.9897669,0.0001491172],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003991103,0.9943683,0.0000171023,0.0001488569,0.0002121658,0.001946744,0.00002228678,0.00003231061,0.002853082],"genre_scores_gemma":[0.01137184,0.9860805,0.00001805738,0.00002014362,0.0004303418,0.0002419937,0.0003067022,0.00007424952,0.001456231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936973,"threshold_uncertainty_score":0.7123514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.202704718501805,"score_gpt":0.4314431802087315,"score_spread":0.2287384617069265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}