{"id":"W1999438938","doi":"10.1016/j.cjca.2014.07.421","title":"QUINAZOLIN-4-PIPERIDIN-4-METHYL SULFAMIDE COMPOUNDS ARE SPECIFIC INHIBITORS OF HUMAN NPP1 AND PREVENT CALCIFICATION OF VALVE INTERSTITIAL CELLS","year":2014,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Sulfamide; Medicine; Pyrophosphatase; Pharmacology; Enzyme; Alkaline phosphatase; Nucleotidase; Calcification; Potency; Biochemistry; Internal medicine; In vitro; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000240307,0.0003778282,0.0003973237,0.0002596509,0.0001865257,0.0001934657,0.0004492022,0.000315826,0.002450112],"category_scores_gemma":[0.0002333207,0.0002299487,0.0001939781,0.0001528629,0.0003118903,0.0001963795,0.0001438648,0.0007530905,0.0002849355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240611,"about_ca_system_score_gemma":0.000280874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000664133,"about_ca_topic_score_gemma":0.002759316,"domain_scores_codex":[0.9998275,0.00003288626,0.00001508362,0.00002744116,0.00003991283,0.00005707557],"domain_scores_gemma":[0.99984,0.00004053526,0.00005291047,0.00001828036,0.00001112829,0.00003719203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007133259,0.0001591537,0.0002042455,0.00009032551,0.00001685016,0.0001503603,0.00003115298,0.0002214788,0.9917426,0.0002969143,0.0002385705,0.006134967],"study_design_scores_gemma":[0.0005173285,0.003461797,0.006480318,0.00001129586,0.00004482582,0.0005494165,0.00003551707,0.000956754,0.9834292,0.0001045107,0.004392544,0.00001652657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985639,0.005290981,0.00450814,0.0003301623,0.0001162468,0.0001524468,0.0005029896,0.0002318463,0.003228235],"genre_scores_gemma":[0.9919397,0.002213728,0.002776204,0.00008404603,0.00002973657,0.00009012267,0.0003816895,0.00002048024,0.002464296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002450112,"threshold_uncertainty_score":0.008196414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138349694008649,"score_gpt":0.2290206164459997,"score_spread":0.2176371195059132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}