{"id":"W1999453256","doi":"10.1016/j.bbrc.2013.02.059","title":"Sortilin turnover is mediated by ubiquitination","year":2013,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Palmitoylation; Endosome; Ubiquitin; Cell biology; Ubiquitin ligase; ESCRT; Golgi apparatus; Lysosome; Transmembrane protein; Chemistry; Transport protein; Transmembrane domain; Biology; Biochemistry; Receptor; Cysteine; Enzyme; Intracellular; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000454728,0.0003895671,0.0004089705,0.0003199302,0.0005176848,0.001496094,0.0002839321,0.0006740183,0.001885536],"category_scores_gemma":[0.000349149,0.0004230445,0.0005494857,0.0002106419,0.0002620938,0.0008691156,0.000600849,0.0005850164,0.001246944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001096739,"about_ca_system_score_gemma":0.0003538277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005824243,"about_ca_topic_score_gemma":0.001036167,"domain_scores_codex":[0.9995623,0.00004164467,0.00005150244,0.0001207523,0.0001143331,0.000109437],"domain_scores_gemma":[0.9996469,0.00004662855,0.0001035983,0.00006503715,0.00006550262,0.00007230676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001202642,0.00007575368,0.003152809,0.0001427736,0.00005618171,0.000252084,0.00003821378,0.0001530893,0.9840134,0.002244503,0.0007528845,0.007915698],"study_design_scores_gemma":[0.00004051924,0.0001057013,0.01970825,0.00001469545,0.00002778419,0.001281353,0.00004193156,0.001872198,0.9713595,0.0005366814,0.004986163,0.00002525604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837405,0.004907459,0.005255133,0.0004817362,0.0001354498,0.00003096031,0.0006590405,0.0002492824,0.004540335],"genre_scores_gemma":[0.9921688,0.0009385215,0.001261379,0.0001024253,0.00001642615,0.00001593803,0.0007126171,0.00002835977,0.004755382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885536,"threshold_uncertainty_score":0.007957458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471980212539183,"score_gpt":0.3224622248881365,"score_spread":0.2877424227627446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}